PTEN 、FHIT基因在胃腺癌中的表达及其意义

目的:探讨PTEN和FHIT基因在胃腺癌中的表达及其临床意义。方法:采用免疫组织化学(Envi-sion二步法)检测56例胃腺癌组织及10例正常胃黏膜组织中PTEN和FHIT基因蛋白的表达。结果:56例胃腺癌组织中PTEN和FHIT蛋白阳性表达率分别为41.1%和46.4%,正常胃黏膜组织均为100%,差异均有统计学意义(P<0.05)。PTEN蛋白的表达与胃腺癌的分化程度、浆膜浸润、淋巴结转移均有关(P<0.05)。FHIT蛋白的表达与胃腺癌淋巴结转移、浆膜浸润无关(P>0.05),与胃腺癌的分化程度有关(P<0.05)。结论:PTEN和FHIT基因蛋白缺失在胃腺癌发生、发展中起重要作用,二者可作为判断胃腺癌生物学行为和临床预后的参考指标。

Expression and significance of PTEN and FHIT in gastric carcinoma

Objective:To investigate the expression of PTEN and FHIT in gastric carcinoma and their clinical significance Methods:The expression of PTEN and FHIT in 56 cases of gastric carcinoma and their normal tissues were detected by Envision.Results:The positive rate of expression of PTEN and FHIT in 56 gastric carcinoma tissue were 41.1% and 46.4% respectively,the paracancerous tissues showed all positive 100%;the differences were statistically significant(P<0.05).PTEN expression was correlated with the differentiation,range of invasion,lymph node metastasis(P<0.05).FHIT expression had no correlation with,range of tumor in invasion,lymph node metastasis(P>0.05),but was related with the degree of differentiation(P<0.05).Conclusion:Decrease or absence expression of PTEN and FHIT protein play an important role in the genesis and development of gastric carcinoma;the two proteins can be used to judge carcinomatous biological behaviors and prognosis.