| 水蛭不同提取物抗凝活性的体外实验研究 |
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| 作者姓名： | Li Y Huang R Sun X |
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| 作者单位： | 军事医学科学院放射医学研究所,北京,100850 |
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| 基金项目： | 国家自然科学基金,北京市自然科学基金 |
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| 摘 要： | 目的:研究水蛭不同提取物的抗凝活性,为水蛭的新药开发提供实验依据.方法:Wistar大鼠腹静脉取血,应用血凝仪体外测定凝血酶原时间(PT)、凝血酶时间(TT)和活化的部分凝血活酶时间(APTT).结果:水蛭的乙酸乙酯部分能使大鼠的PT、TT、APTT显著延长.正己烷部分、水溶液部分能使大鼠的PT显著延长,正丁醇部分能使大鼠的APTT显著延长.结论:水蛭各提取物均有抗凝活性,水蛭中存在不同于水蛭素的新的抗凝血成分.
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| 关 键 词： | 水蛭 抗凝血 提取物 |
| 修稿时间： | 2003年6月5日 |
Experimental studies on anticoagulant activity of different extract of leech in vitro |
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| Li Y,Huang R,Sun X.Experimental studies on anticoagulant activity of different extract of leech in vitro[J].Jorunal of Chinese Medicinal Materials,2004,27(2):123-125. |
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| Authors: | Li Yanling Huang Rongqing Sun Xiaodong |
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| Institution: | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850. |
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| Abstract: | Objective: To study the anticoagulant activity of different extracts of Leech. Methods: Prothrombin time(PT), thrombin time(TT) and activated partial thromboplastin time(APTT) were determined by coagulometer for blood samples collected from abdominal vein of Wistar rat. Results: PT, TT, APTT were prolonged remarkably by ethyl acetate part of Leech. PT was prolonged remarkably by hexane part and aqueous solution part of Leech. APTT was prolonged remarkably by n-Butylalcohol part of Leech. Conclusion: The different extracts of Leech have obvious anticoagulant effects. There are new anticoagulant components different from hirudin in Leech. |
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| Keywords: | Leech Anticoagulant Extract |
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