经皮脾内无水酒精注射治疗肝硬化脾功能亢进临床研究

目的：探讨脾内无水酒精注射治疗肝硬化脾功能亢进的疗效和远期效果。方法：对符合入选条件的患者，在B超引导下进行经皮穿刺脾内无水酒精注射，剂量为1．0—2．0ml，每周1次，根据病情确定次数，注射前后自身对照，观察外周血细胞变化；设药物对照组，观察两组出血率、生存率。结果：治疗组患者治疗后外周血白细胞、血小板及血红蛋白含量较治疗前升高(P＜0．05)；脾长度、脾厚度及门静脉宽度较治疗前缩小(P＜0.05)；与对照组比较出血人次减少、生存人数增加，差异有显著性意义(P＜0.05)。结论：此方法疗效肯定，副作用小、费用低、设备要求低、操作易掌握、病人易接受、适宜于基层医院开展。

Clinical Study of Injecting Dehydrated Alcohol by Transcutaneous Intraspleen in Treatment of Liver Cirrhosis with Hypersplenism

Objective: To investigate the curative effect and long-term follow-up result of injecting dehydrated alcohol by transcutaneous intraspleen in treatment of liver cirrhosis with hypersplenism. Methods: Led by B style ultrasound, injected dehydrated alcohol by transcutaneous intraspleen in treatment of liver cirrhosis with hypersplenism to the patients who were selected in accordance with stansard, treatment dose 1.0 to 2.0ml, once a week, the total course of treatment was one to fiver times, different condition different times, compared with themself before and after treatment, observed the changes of peripheral blood cells; estabised medicine comparison, observed the changes of rates of hemorrhage and survive. Result: The peripheral blood cells, platelet and content of hemoglobin after treatment were significantly higher than that of untreatment (P< 0.05); the splenic length and thickness, pylic widths were shorter than that of untreatment (P<0.05); the rate of hemorrhage decreaed, while the rate of survive increased. Conclusion: This way is easy to accept for patients and suitable to develop in basic level hospital because of it's definite curative effect, simple equipment, inexpensive costs, convenient operation and little side effect.