初诊高血压病患者微量白蛋白尿和动脉粥样硬化的关系分析

目的]探讨高血压病(EH)患者微量白蛋白尿(MAU)与动脉粥样硬化的关系。方法]选择高血压病患者52例,根据24h尿白蛋白定量分成正常白蛋白尿组(NMCA组)和微量白蛋白尿组(MCA组)。采用免疫比浊法测定24h尿微量白蛋白含量;采用彩色多普勒超声检测颈总动脉内-中膜厚度(IMT)及其动脉粥样斑块发生率。结果](1)MCA组较NMCA组患者的收缩压(SBP)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、MAU统计学上有显著性差异,而其他指标年龄、体重指数(BMI)、舒张压(DBP)、空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)本实验中无统计学差异。(2)MCA组较NMCA组患者的IMT、斑块发生率统计学上有显著性差异。(3)平均IMT和最大IMT与年龄、MAU呈显著正相关,与其他指标无明显相关。结论]EH患者MAU和颈总动脉内-中膜厚度、动脉粥样斑块发生率密切相关。

Analysis on Relationship between Hypertension Patients' Slight Albumen Urine and Atherosclerosis of First Diagnosis

Objective] To discuss the relation between EH patients' MAU and atherosclerosis.Method]Select 52 cases,under 24h urinary albumen quantity,divide them into NMCA group and slight MCA group.Take immune turbid comparison method to measure 24h slight albumen;take Color Doppler Ultrasonic Examination to test IMT of common carotid artery and occurring rate of atherosclerosis spots.Result]There's more marked statistical difference on SBP,HOL-C,LDL-C,MAU in the MCA than the NMCA group,while others no statistical difference,such as ages,BMI,DBP,FBG,TC and TG;MCA group had more marked statistical difference than NMCA group on IMT and spots occurring rate;the average IMT and max IMT was in positive relation with age and MAU,without obvious relation with other indexes.Conclusion]EH patients' MAU was closely related with IMT in the common carotid artery and spots occurring rate of atherosclerosis.