特发性脊柱侧凸患者全血中硒元素和血清中铁、铜、锌元素含量的变化

目的 调查研究特发性脊柱侧凸患者血清中铁、铜、锌元素含量及患者全血中硒元素含量.方法 对特发性脊柱侧凸患者进行全血和血清标本采集及微量元素测定,并与正常对照组进行比较.病例组男15例,女15例,年龄为8～19岁.侧凸度数为10°～65°.对照组25例为体检正常志愿者,其中男12例,女13例,年龄为7～19岁,无侧凸.结果病例组Se元素含量（23.45±10.99） μg/L与对照组（57.91±47.83） μg/L相比,差异有统计学意义（P＜0.01）;病例组Fe元素含量（1.21±0.62） mg/L与对照组（1.16±0.46） mg/L相比,差异无统计学意义;病例组Cu元素含量（0.70±0.14） mg/L与对照组（0.74±0.15） mg/L相比,差异无统计学意义;病例组Zn元素含量（0.77±0.20） mg/L与对照组（0.70±0.20） mg/L相比,差异无统计学意义.结论 Se元素缺乏可能导致胶原纤维和胶原蛋白合成障碍,降低了纤维稳定性,进一步导致脊柱侧凸.

Changes of Selenium content in blood and Ferrum, Copper, Zinc content in serum of patients with idiopathic scoliosis

Objective To extend investigate and discuss changes of Selenium content in blood and Ferrum, Copper, Zinc content in serum of patients with idiopathic scoliosis. Methods A total of 30 patients （ 15 female and 15 male, aged 8-19 years, degree of spine curvature deformity 10°- 65°） with idiopathic scoliosis were examined and compared with normal con- trol group（ 13 female and 12 male, aged 7-19 years）. Results There was statistical significance between scoliosis gorup （23.45 ± 10.99） μg/L and control group （57.91 ± 47.83） μg/L of selenium concentration （P 〈 0.01 ）. There was no sta- tistical significance between scoliosis gorup （1.21 ±0.62） mg/L and control group （1.16 -± 0.46） mg/L of Ferrum content in serum. There was no statistical significance between scoliosis gorup （0.70 ± 0.14） mg/L and control group （0.74 ± 0.15 ） mg/L of Copper content in serum. There was no statistical significance between scoliosis gorup （0.77 ± 0.20） mg/L and control group（0.70 ±0.20） mg/L of Zinc： content in serum. Conclusion The Se element deficiency may lead to dys- synthesis of collagen fibers and collagen protein, reduce the stability of fiber, and further lead to scoliosis.