新疆维吾尔族人群血液生化指标与缺血性脑卒中关联分析

目的探讨新疆维吾尔族人群缺血性脑卒中发病风险与相关血液生化指标的关系。方法采用1:1配对的病例对照研究设计,对所选择的研究对象进行调查。结果总蛋白水平、白蛋白水平、血糖水平、高密度脂蛋白水平存在统计学差异。单因素Logistic回归分析,总蛋白(OR=0.85,95%CI:0.80～0.90)、白蛋白(OR=0.79,95%CI:0.73～0.85)及高密度脂蛋白(OR=0.06,95%CI:0.02～0.18)为缺血性脑卒中的保护因素,高血糖(OR=1.35,95%CI:1.14～1.60)为缺血性脑卒中的危险因素;多因素Logistic回归分析表明白蛋白(OR=0.86,95%CI:0.75～0.99)及高密度脂蛋白(OR=0.32,95%CI:0.15～0.64)为独立保护因素。结论高血糖可能增加缺血性脑卒中的发病风险,血液中白蛋白与高密度脂蛋白可能与维吾尔族人群缺血性脑卒中的易感性相关。

Association between blood biochemical indicators and ischemic stroke in Xinjiang Uyghur population

Objective To explore the relationship between the incidence of ischemic stroke and blood biochemical indicators in Xinjiang Uyghur population.Methods The selected population was investigated with the design of 1∶1 matched case-control study.Results The statistical difference was found in the level of total protein,albumen,blood glucose and HDL between cases and controls.High levels of total protein（OR=0.85,95% CI：0.80～0.90）,Albumen（OR=0.79,95% CI：0.73～0.85） and HDL（OR=0.06,95% CI：0.02～0.18） were protective factors of ischemic stroke,and high plasma glucose concentration（OR=1.35,95% CI：1.14～1.60） increased the risk of ischemic stroke while analyzed by factor Logistic regression.Albumen（OR=0.86,95% CI：0.75～0.99） and HDL（OR=0.32,95% CI：0.15～0.64） were independent protective factors of ischemic stroke by multi-factors Logistic regression analysis.Conclusions High plasma glucose concentration might increase the risk of ischemic stroke and the level of albumen and HDL are possibly related to the susceptibility to ischemic stroke in Xinjiang Uyghur population.