| P38信号转导通路对蛛网膜下腔出血后迟发性脑血管痉挛的影响 |
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| 引用本文： | 余亚娟,柯国平. P38信号转导通路对蛛网膜下腔出血后迟发性脑血管痉挛的影响[J]. 武汉大学学报(医学版), 2009, 30(5) |
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| 作者姓名： | 余亚娟 柯国平 |
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| 作者单位： | 武汉大学医学院人体解剖学教研室,湖北,武汉,430071;咸宁学院医学院内科学教研室,湖北,咸宁,437100;武汉大学医学院人体解剖学教研室,湖北,武汉,430071 |
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| 摘 要： | 目的:探讨促分裂原活化蛋白激酶P38(P38 MAPK)在兔蛛网膜下腔出血(SAH)后迟发性脑血管痉挛(CVS)中的作用。方法:35只新西兰白兔随机分为对照组(n=5),SAH组(n=10)、SAH+DMSO(n=10)、SAH+SB203580组(n=10),采用枕大池二次注血的方法建立SAH模型。分别在注血后第5天、第7天活体灌注处死,留取基底动脉标本。用免疫组织化学、测量基底动脉横截面积的方法检测P38 MAPK的表达和CVS程度的变化。结果:5 d处死的SAH组、SAH+DMSO组兔基底动脉横截面积与对照组相比有统计学意义(P<0.01),平滑肌细胞P38 MAPK的表达与对照组相比显著增强(P<0.01);5 d处死的SAH+SB203580组CVS明显缓解(P<0.01),平滑肌细胞P38 MAPK的表达减弱。结论:SAH后兔基底动脉平滑肌细胞内激活的P38 MAPK诱导了迟发性CVS的产生;SB203580能够有效的缓解基底动脉平滑肌持续性的收缩。
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| 关 键 词： | 促分裂原活化蛋白激酶P38 蛛网膜下腔出血 脑血管痉挛 信号转导 |
Effects of P38 Mitogen-Activated Protein Kinase Signal Transduction Pathway in Delayed Cerebral Vasospasm After Subarachnoid Hemorrhage |
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| YU Yajuan,KE Guoping. Effects of P38 Mitogen-Activated Protein Kinase Signal Transduction Pathway in Delayed Cerebral Vasospasm After Subarachnoid Hemorrhage[J]. Medical Journal of Wuhan University, 2009, 30(5) |
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| Authors: | YU Yajuan KE Guoping |
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| Affiliation: | YU Yajuan1,2,KE Guoping11Dept.of Anatomy,School of Medicine,Wuhan University,Wuhan 430071,China2Dept.of Internal Medicine,Medical School of Xianning College,Xianning 437100,Hubei,China |
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| Abstract: | Objective: To study the role of P38 MAPK in the development of delayed cerebral vasospasm after subarachnoid hemorrhage(SAH).Methods: Thirty-five New Zealand white rabbits were divided randomly into four group: control(n=5),SAH(n=10),SAH+DMSO(n=10),and SAH+SB203580(n=10) groups.The SAH model was established by using blood injection via cisternal puncture twice.The perfusion-fixation was performed respectively on the 5th and 7th day after blood-injection in vivo and the entire length of basilar artery was ha... |
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| Keywords: | P38 MAPK Subarachnoid Hemorrhage Cerebral Vasospasm Signal Transduction |
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