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| 中药复方癌宁对人胃腺癌细胞凋亡基因表达的影响 | |
| 引用本文： | 苏勉诚,戴梅,吕晓英,李红坤,刘继林.中药复方癌宁对人胃腺癌细胞凋亡基因表达的影响[J].中药材,2002,25(8):563-566. |
| 作者姓名： | 苏勉诚 戴梅 吕晓英 李红坤 刘继林 |
| 作者单位： | 1. 广东省珠海市国家中药现代化工程技术研究中心,519020 2. 重庆市沙坪坝区中医院,400030 3. 四川大学公卫学院,成都,610041 4. 成都中医药大学,610075 |
| 摘 要： | 目的:探索癌宁对体外人胃癌细胞基因表达的影响。方法:采用流式细胞术,检测了中药复方癌宁及顺铂诱导胃癌细胞凋亡基因的表达。结果:顺铂、癌宁组与空白对照比较,bcl-2、c-myc基因表达产物含量显著降低,p~(53)、bax基因表达产物含量显著增高(P<0.01),bax/bcl-2比值显著增高。结论:癌宁对人胃癌细胞的诱导凋亡作用与其对癌基因、抑癌基因表达的改变有关。 |
| 关 键 词： | 中药复方 癌宁 基因 凋亡 |
| 修稿时间： | 2002年2月26日 |
Effect of Traditional Chinese Medicine Compounds Aining on the Expression of Apoptosis Inducing Genes of Human Gastric Cancer Cell |
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| Su Miancheng.Effect of Traditional Chinese Medicine Compounds Aining on the Expression of Apoptosis Inducing Genes of Human Gastric Cancer Cell[J].Jorunal of Chinese Medicinal Materials,2002,25(8):563-566. | |
| Authors: | Su Miancheng |
| Institution: | National Engineering Research Center for Mordernization of TCM, Zhuhai 519020. |
| Abstract: | Objective: To investigate the effects of Aining on the genes of the human gastric cancer cells. Methods: Flow cytometry( FMC) was adopted to detect the gene expression of the gastric cancer cell in the Aining group, the cisplatin(DDP)group and the blank group. Results: Compared with the blank group, the expression of c-myc and bcl-2 genes was low, while that of the p53,bax genes was high(P< 0.01) ,and the ratio of bax/bcl-2 significantly increased in both the Aining group and the cisplatin(DDP)group. Conclusions: The mechanism of inducing the human gastric cancer cells apoptosis by Aining has some relationship with the changes of the genes. |
| Keywords: | Traditional Chinese medicine compounds Aining Gene Apoptosis |
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