α-干扰素治疗重症轮状病毒肠炎72例疗效观察

目的观察α-干扰素治疗重症轮状病毒肠炎的临床效果。方法将142例重症轮状病毒肠炎,按照随机方法分为两组。对照组：应用病毒唑,10-15 mg/（kg.d）^-1,1次/d,静脉滴注,连用5 d;治疗组：应用α-干扰素2.0万U/（kg.d）^-1,1次/d,肌注,连用3 d。其他治疗两组相同。结果治疗组72例,12 h内治疗者26例,总有效26例,占100%。其中,显效24例,占92.3%;12-24 h治疗者24例,显效17例,占70.8%;24-48 h治疗者22例,显效9例,占40.9%。各组间均具有显著性差异（P〈0.05）。对照组70例中,12 h内治疗者23例,12-24 h治疗者28例,24-48 h治疗者19例,均无效,无效率均为100%。结论α-干扰素治疗重症轮状病毒肠炎具有极显著效果,而且用药越早效果越显著。病毒唑治疗该病无效。

Observation of Interferon-Treated the Serve Rotanvi rus Diarrhea in 72 Cases

Objective To observe the effect of Interferontreated with the serve mtanvirus diarrhea. Methods There were 142 cases suffering from serve mtanvirus diarrhea to divide into 2 groups, according to Random. Control group were treated with Ribavirin, 10- 15 mg/（kg·d）^-1, iv drip qd × 5. Interferon group were treated with Interferon, 20 000 U/ （kg· d）^-1, im qd3. Other treatment of 2 groups were identical. Results There were 72 cases in Interferon group. Beginning treatment within illness after 12 hours were 26 cases, effect were 26 cases （ 100% ）, marked effect were 24 cases （92.3%）; 12- 24 hours were 24 cases, marked effect were 17 cases （70.8%）; 24- 48 hours were 22 cases, effect were 22 cases （100%）, marked effect were 9 cases （40.9%）. From each other groups were statistically marked difference （ P 〈 0.05）, to marked effect to respond to Interferon. There were 70 cases in control group, Beginning treatment wi thin illness after 12 hours were 23 cases, 12 - 24 hours were 28 cases, 24 - 48 hours were 19 cases. The all cases were fall-to respond to Ribavirin. Conclusion Interferon in treating serve rotanvirus diarrhea has significant function, and if the treatment were earlier, the effect were better.