葛根素注射液对变异型心绞痛患者内皮功能的影响

目的：观察葛根素注射液对变异型心绞痛的治疗效果及对内皮功能的影响。方法：对48例变异型心绞痛患者随机分成治疗组（A组）及对照组（B组），治疗组用葛根素注射液300－500mg静滴，每日1次；对照组用常规治疗方法，10－14日为1个疗程。观察2组用药前后内皮互（ET）及一氧化氮（NO）的变化。结果：治疗后2组临床症状缓解，心电图改善，但与治疗前比较无统计学意义；而治疗组ET和NO治疗前后比较具有显著性差异。结论：葛根素注射液对变异型心绞痛不仅能改善临床症状及心电图，且能改善内皮细胞的功能。

Influence of puerarininjection(

Objective:To observe the curative effects of puerarin injection(葛根素注射液) on variant angina pectoris(VAP) and its influences on endothelial functions.Methods:Fortyeight cases with VAP were randomly divided into treated and control group.The treated group was treated with puerarin injection 300500 mg infused intravenously once a day，meanwhile the control group treated with conventional therapy.The therapeutic course was 1014 days for both groups.Before and after using drugs the changes in endothelin(ET) and nitric oxide (NO) were observed in two groups.Results:In both groups after therapy the clinically symptomatic convalescences and changes in electrocardiography (ECG) compared with before therapy had significant differences,but in comparison between two groups the differences had not statistical significant.Otherwise regarding to the ET and NO the differences were significant between treated group and control group.Conclusions:Puerarin injection not only possesses obviously curative effects on symptomatic convalescence and ECG changes but also is able to improve the endothelial functions.