动态检测C反应蛋白及降钙素原预测多发伤后多器官功能障碍综合征的发生

目的 探讨多发伤患者外周血C反应蛋白(CRP)和降钙素原(PCT)与多器官功能障碍综合征(MODS)的相关性.方法 将136例多发伤患者按治疗过程中有无MODS发生分为MODS组(49例)和非MODS组(87例),另选50例健康志愿者作为对照组,检测三组患者外周血不同时间点CRP和PCT含量.结果 MODS组的外周血CRP含量的最高值出现在伤后48 h(38.7±2.7)mg/L],且在伤后各时间点与非MODS组及对照组比较差异有统计学意义(P＜0.05).MODS组外周血PCT含量的最高值出现在伤后24h(20.3±1.7)μg/L],且在伤后各时间点与非MODS组及对照组比较差异有统计学意义(P＜0.05).结论 创伤后急性期CRP和PCT含量与MODS的发生均具有相关性.联合测定对MODS预测更为可靠,具有较高的临床价值.

Dynamic detection of C-reactive protein and procalcitonin to predict the occurrence of multiple organ dysfunction syndrome after multiple trauma

Objective To investigate the relation of the peripheral blood C-reactive protein (CRP)and procalcitonin (PCT) and multiple organ dysfunction syndrome( MODS ) for patients with multiple trauma.Methods A total of 136 patients with multiple trauma were divided into MODS group (49 cases) and non MODS group (87 cases),and 50 healthy volunteers were chosen as control group. Peripheral blood CRP and PCT concentration were detected at different times. Results The highest concentration of peripheral blood CRP in MODS group was appeared on 48 h (38.7 ± 2.7) mg/L], CRP concentrations in MODS group were significantly different with non MODS group and control group (P ＜0.05). The highest concentration of peripheral blood PCT in MODS group was appeared on 24 h (20.3 ± 1.7)μ g/L], PCT concentrations in MODS group were significantly different with non MODS group and control group (P＜ 0.05). Conclusions CRP and PCT are relevant to the occurrence of MODS in trauma acute stage. The observation of peripheral blood CRP and PCT concentrations can predict the occurrence of MODS.