声门上型喉癌和下咽癌原发灶与淋巴结转移灶肿瘤转移特性研究

目的比较声门上型喉癌、下咽癌原发灶与淋巴结转移灶肿瘤转移特性。方法应用免疫组织化学方法观察了41例病理证实有淋巴结转移的声门上型喉癌、下咽癌患者的原发灶与淋巴结转移灶肿瘤的CD44表达情况。结果CD44蛋白表达与声门上型喉癌、下咽癌的临床分期和病理分级无关（P〉0．05）。原发灶肿瘤与淋巴结转移灶肿瘤CD44表达阳性率分为85．4％和63．4％，差异有统计学意义（P〈0．05）。同一患者淋巴结转移灶的CD44表达强度与原发灶比较，表达增强和减弱无差异（P〉0．05）。结论声门上型喉癌、下咽癌淋巴结转移灶肿瘤的转移性并不比原发灶肿瘤强。

The metastasis feature of the primary and metastatic lymph node lesions in supraglottic and hypopharyngeal cancer

Objective To investigate the metastasis feature of primary and metastatic lymph node lesions in supraglottic or hypopharyngeal cancer. Methods The specimens from the primary and metastatic lymph node lesions of 41 patients with supraglottic or hypopharyngeal cancer were stained with immunohistochemistry method to determine the expression of CD44. Results No correlation was found between the expression of CD44 and clinical staging and pathological grading of the supraglottic or hypopharyngeal cancer （ P 〉 0. 05 ）. The CD44 positive expression rates in primary and metastatic lymph node lesions were 85.4% and 63% respectively. There was a significant difference between primary and metastatic lymph node lesions （ P 〈 0.05 ）. There was no significant difference in the intensity of CD44 expression in the same patient between primary and metastatic lymph node lesions （ P 〉 0.05 ）. Conclusion The metastatic incidence of metastatic focus in supraglottic or hypopharyngeal cancer is not higher than that of primary pathological focus.