Long term clinical outcome of peripheral nerve stimulation in patients with chronic peripheral neuropathic pain |
| |
| Authors: | Frank Van Calenbergh Jan Gybels Koen Van Laere Patrick Dupont Leon Plaghki Bart Depreitere Ron Kupers |
| |
| Affiliation: | 1. Department of Neurosurgery, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium;2. Department of Nuclear Medicine, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium;3. Unité READ, Faculty of Medicine, Université Catholique de Louvain, Brussels, B-1200, Belgium;4. PET Center & Department of Surgical Pathophysiology, Rigshospitalet, Copenhagen, DK-2100, Denmark;1. Departments of Oral and Maxillofacial Surgery and Neural and Pain Sciences, and Brotman Facial Pain Center, University of Maryland School of Dentistry, Baltimore, Maryland;2. Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;3. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;5. Department of Endodontics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;9. Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;4. Regional Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;7. Department of Community Dentistry and Behavioral Science, University of Florida, College of Dentistry, and Pain Research and Intervention Center of Excellence, Gainesville, Florida;11. Department of Oral Diagnostic Sciences, University at Buffalo, Buffalo, New York;12. Battelle Memorial Institute, Durham, North Carolina;8. Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;1. Center for Pain Studies, Rehabilitation Institute of Chicago, Chicago, Illinois;2. Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, Illinois;3. Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee;4. Texas Orthopedics, Austin, Texas;1. Cátedra de Farmacología, Facultad de Farmacia y Bioquímica (Universidad de Buenos Aires), Junín 956, 5° piso, 1113 Buenos Aires, Argentina;2. Instituto de Investigaciones Farmacológicas (CONICET-UBA), Junín 956, 5° piso, 1113 Buenos Aires, Argentina |
| |
| Abstract: | BackgroundChronic neuropathic pain after injury to a peripheral nerve is known to be resistant to treatment. Peripheral nerve stimulation is one of the possible treatment options, which is, however, not performed frequently. In recent years we have witnessed a renewed interest for PNS. The aim of the present study was to evaluate the long-term clinical efficacy of PNS in a group of patients with peripheral neuropathic pain treated with PNS since the 1980s.MethodsOf an original series of 11 patients, 5 patients could be invited for clinical examination, detailed assessment of clinical pain and QST examination. The assessments were done both during habitual use of PNS and with the stimulator off.ResultsAverage pain intensity and pain unpleasantness ratings as assessed with visual analog and verbal rating scales showed significant beneficial effects of PNS. Quality of life measures (sleep and daily functioning) also showed positive effects. Quantitative Sensory Testing results did not show significant differences in cold pain and heat pain thresholds between the “ON” and “OFF” conditions.ConclusionIn selected patients with peripheral neuropathic pain PNS remains effective even after more than 20 years. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
