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Brain connectivity in non-reading impaired children and children diagnosed with developmental dyslexia
Authors:Timothy N. Odegard  Emily A. Farris  Jeremiah Ring  Roderick McColl  Jeffrey Black
Affiliation:1. National Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, PR China;2. Department of Psychology and Social Behavior, University of California, Irvine, CA 92697, USA;3. Center for Cognitive and Behavioral Brain Imaging, Department of Psychology, Ohio State University, Columbus, OH 43210, USA;4. Center for Studies of Psychological Application and School of Psychology, South China Normal University, Guangzhou 510631, China;5. Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA;6. Faculty of Psychology, Southwest University, Beibei, Chongqing, 400715, China;7. Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China;8. National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China;1. Electronics Laboratory, Department of Physics, University of Patras, Greece;2. Artificial Intelligence & Information Analysis Laboratory, Department of Informatics, Aristotle University, Thessaloniki, Greece;3. Department of Medicine (Laboratory L. Widén), University of Crete, Greece;4. Department of Pediatrics, The University of Tennessee Health Science Center, USA;5. Department of Medicine, University of Crete, Greece;6. Department of Psychology, University of Houston, USA
Abstract:Diffusion Tensor Imaging (DTI) was used to investigate the relationship between white matter and reading abilities in reading impaired and non-reading impaired children. Seventeen children (7 non-reading impaired, 10 reading impaired) participated in this study. DTI was performed with 2 mm isotropic resolution to cover the entire brain along 30 noncollinear directions. Voxelwise analyses were conducted on data processed through Tract Based Spatial Statistics (TBSS). The data replicated previous results seen across multiple studies and extended findings to include measures of both real word and pseudoword decoding. Negative correlations were observed in the left posterior corpus callosum between fractional anisotropy (FA) values and both measures of decoding. Positive correlations between FA values and real word and pseudoword decoding were observed in the left superior corona radiata. This extension of findings regarding correlations between the corona radiata and reading skills suggests an important direction for future research into the neurological substrates of reading.
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