Predictors of Variation in Serum IGFI and IGFBP3 Levels in Healthy African American and White Men |
| |
Authors: | Cathrine Hoyo Janet Grubber Wendy Demark-Wahnefried Bruce Lobaugh Amy S Jeffreys Steven C Grambow Jeffrey R Marks Temitope O Keku Phillip J Walther Joellen M Schildkraut |
| |
Institution: | 1. Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina;2. Department of Surgery, Division of Urology, Duke University Comprehensive Cancer Center, Durham, North Carolina;3. Department of Obstetrics and Gynecology, Division of Oncology, Duke University Comprehensive Cancer Center, Durham, North Carolina;4. Department of Biostatistics and Bioinformatics, Duke University Comprehensive Cancer Center, Durham, North Carolina;5. Department of Experimental Surgery, Duke University Comprehensive Cancer Center, Durham, North Carolina;6. School of Nursing, Duke University Comprehensive Cancer Center, Durham, North Carolina;7. Cancer Detection, Prevention and Control Program, Duke University Comprehensive Cancer Center, Durham, North Carolina;8. Epidemiologic Research and Information Center, Veterans Administration Medical Center, Durham, North Carolina;9. Department of Medicine, Division of Gastroenterology, University of North Carolina, Chapel Hill, North Carolina |
| |
Abstract: | BackgroundIndividual variation in circulating insulinlike growth factor-1 (IGF1) and its major binding protein, insulinlike growth factor binding protein-3 (IGFBP3), have been etiologically linked to several chronic diseases, including some cancers. Factors associated with variation in circulating levels of these peptide hormones remain unclear.MethodsMultiple linear regression models were used to determine the extent to which sociodemographic characteristics, lifestyle factors, personal and family history of chronic disease, and common genetic variants, the (CA)n repeat polymorphism in the IGF1 promoter and the IGFBP3-202 A/C polymorphism (rs2854744) predict variation in IGF1 or IGFBP3 serum levels in 33 otherwise healthy African American and 37 white males recruited from Durham Veterans Administration Medical Center.ResultsPredictors of serum IGF1, IGFBP3, and the IGF1: IGFBP3 molar ratio varied by race. In African Americans, 17% and 28% of the variation in serum IGF1 and the IGF1:IGFBP3 molar ratio, were explained by cigarette smoking and carrying the IGF1 (CA)19 repeat allele, respectively. Not carrying at least 1 IGF1 (CA)19 repeat allele and a high body mass index explained 8% and 14%, respectively, of the variation IGFBP3 levels. These factors did not predict variation of these peptides in whites.ConclusionIf successfully replicated in larger studies, these findings would add to recent evidence, suggesting known genetic and lifestyle chronic disease risk factors influence IGF1 and IGFBP3 circulating levels differently in African Americans and whites. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|