A failure to grasp the affective meaning of actions in autism spectrum disorder subjects |
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| Authors: | J Grèzes B Wicker S Berthoz B de Gelder |
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| Institution: | 1. Laboratoire de Neurosciences Cognitives, INSERM U960 & DEC, Ecole Normale Supérieure, 29 Rue d’Ulm, 75005 Paris, France;2. Institut de Neurosciences Cognitives de la Méditerranée, CNRS, Université de Provence, Marseille, France;3. INSERM U669 & Institut Mutualiste Montsouris, Universités Paris Sud & Paris René Descartes, Paris, France;4. Donders Laboratory for Cognitive and Affective Neurosciences, Tilburg, The Netherlands;1. Centre de Neuroscience Cognitive, UMR 5229, CNRS, Bron, France;2. Inserm U 955, AP-HP, FondaMental Foundation, Department of Psychiatry, University Hospital Mondor, Créteil, France;1. University of Washington, Department of Psychology, Box 351525, Seattle, WA 98195, USA;2. University of Washington, Department of Psychiatry and Behavioral Sciences, Box 356560, Room BB1644, Seattle, WA 98195, USA;3. Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, WA 98101, USA;4. University of Washington, Department of Medicine, Division of Medical Genetics, Box 356420, Seattle, WA 98195, USA;5. University of Washington, Department of Biostatistics, Box 357232, Seattle, WA 98195, USA;1. Institute of Cognitive Neuroscience, University College London, London, WC1N 3AR, UK;2. Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany |
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| Abstract: | The ability to grasp emotional messages in everyday gestures and respond to them is at the core of successful social communication. The hypothesis that abnormalities in socio-emotional behavior in people with autism are linked to a failure to grasp emotional significance conveyed by gestures was explored. We measured brain activity using fMRI during perception of fearful or neutral actions and showed that whereas similar activation of brain regions known to play a role in action perception was revealed in both autistics and controls, autistics failed to activate amygdala, inferior frontal gyrus and premotor cortex when viewing gestures expressing fear. Our results support the notion that dysfunctions in this network may contribute significantly to the characteristic communicative impairments documented in autism. |
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