Relationship between perilipin gene polymorphisms and body weight and body composition during weight loss and weight maintenance |
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| Authors: | Stijn Soenen Edwin CM Mariman Neeltje Vogels Freek G Bouwman Marcel den Hoed Louise Brown Margriet S Westerterp-Plantenga |
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| Institution: | 1. Department of Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan;2. Fukui Saiseikai Hospital, Fukui, Japan;3. Nasu Neurosurgery Hospital, Tochigi, Japan;4. Department of Hematology, Kanazawa University Hospital, Kanazawa, Japan;1. Department of Surgery, Division of Cardiac Surgery, Austria;2. Department of Internal Medicine II, Division of Cardiology, Austria;3. Clinical Department of Medical and Chemical Laboratory Diagnostics, Austria;4. Department of Clinical Pharmacology, Medical University of Vienna, Austria;1. State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China;2. National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100193, China;3. Department of Physiology and Pathophysiology, Peking (Beijing) University Health Science Center, 38 Xueyuan Road, Beijing 100083, China |
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| Abstract: | BackgroundGenetic variation in the perilipin (PLIN) gene may play a role in the etiology and treatment of obesity.ObjectiveTo examine different polymorphisms in the PLIN gene in relation to body-weight regulation.Methods118 subjects followed a 6 wk VLCD, followed by 1 year weight maintenance. Body-weight (BW), body-composition, leptin concentration, and polymorphisms of the PLIN gene: PLIN1:rs2289487, PLIN4:rs894160, PLIN6:rs1052700, PLIN5:rs2304795 and PLIN7:rs 2304796 were determined.ResultsBW loss during VLCD was 7.0 ± 3.1 kg (p < 0.05), and BW regain was 3.7 ± 1.4 kg (p < 0.05), including changes in body mass index (BMI), waist-circumference, body-composition and leptin concentrations (p < 0.05).Linkage disequilibria were observed between PLIN1 and PLIN4: D' > 0.9, r2 = 0.72; PLIN5 and PLIN7: D' > 0.9, r2 = 0.85.In men, body weight, BMI, waist circumference, body fat, leptin concentrations were significantly lower for the haplotype of PLIN1 (C-alleles) and PLIN4 (A-alleles). In women weight loss and loss of fat mass were larger for the haplotype of PLIN1 (C-alleles) and PLIN4 (A-alleles). For PLIN6 genotypes body weight and body fat were lower for homozygotes of the minor allele (T/T) in the men; in the women leptin concentrations were lower.The haplotype of PLIN5 and PLIN7 consisting of A/G and G/G of PLIN5 and A/A of PLIN7 showed a reduction in FM: 5.9 ± 0.6 kg vs 3.1 ± 0.4 kg, % body fat: 5.5 ± 0.6% vs 2.2 ± 0.2%, and leptin: 20.5 ± 10.8 ng/ml vs 12.9 ± 6.7 ng/ml over time in the women (p < 0.05).ConclusionSince the haplotype of the minor alleles PLIN1–4, PLIN5–7 and PLIN6, was related to body-weight regulation at a lower level of body-weight in the men as well in the women we conclude that the PLIN1–4, 6, and 5–7 locus appears as a genetic influencer of obesity risk in humans. |
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