| IL-12协同B7-1增强实验小鼠的抗肿瘤免疫 * |
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| 引用本文： | 王志华,康熙雄,谷宪三朗,住本秀敏,中畸有恒,浅野茂隆.IL-12协同B7-1增强实验小鼠的抗肿瘤免疫 *[J].中国肿瘤生物治疗杂志,2000,7(1):46-49. |
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| 作者姓名： | 王志华 康熙雄 谷宪三朗 住本秀敏 中畸有恒 浅野茂隆 |
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| 作者单位： | |
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| 基金项目： | * 黑龙江省自然科学基金(D9518)资助 |
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| 摘 要： | 目的：探讨分叉双歧杆菌的完整肽聚糖对巨噬细胞功能的调节作用。方法：以完整肽聚糖注射于源鼠腹腔，用习胸腺细胞增殖法、１９２９细胞体外杀伤法及Ｇｒｉｅｓｓ试剂分别测定裸鼠腹腔巨噬细胞产生的ＩＬ－１，ＴＮＦ－α及ＮＯ的水平；同时也观察了巨噬细胞体外杀瘤活性的变化。结果：完整肽聚糖一裸鼠腹腔巨噬细胞产生的ＩＬ－１，ＴＮＦ－α及ＮＯ含量均显著高于对照组，体外杀瘤活性也明显增强（Ｐ〈０．０１）。结论：分叉双歧
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| 关 键 词： | 双歧杆菌 完整肽聚糖 巨噬细胞 肿瘤 基因治疗 |
| 收稿时间： | 1999/5/17 0:00:00 |
| 修稿时间： | 1999/11/8 0:00:00 |
IL-12 Synergizes B7-1 Enhance the Antitumor Immunity in Experimental Mice |
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| Wang Zhihu,Kang Xixiong,Kenzaburo Tani,Hidetoshi Sumimoto,Yakon Nakazaki and Shigetaka Asano.IL-12 Synergizes B7-1 Enhance the Antitumor Immunity in Experimental Mice[J].Chinese Journal of Cancer Biotherapy,2000,7(1):46-49. |
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| Authors: | Wang Zhihu Kang Xixiong Kenzaburo Tani Hidetoshi Sumimoto Yakon Nakazaki and Shigetaka Asano |
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| Institution: | Institute of Oncology,Harbin Medical University,Harbin 150040;Institute of Oncology,Harbin Medical University,Harbin 150040;Institute of Oncology,Harbin Medical University,Harbin 150040;Institute of Oncology,Harbin Medical University,Harbin 150040;Institute of Oncology,Harbin Medical University,Harbin 150040;Institute of Oncology,Harbin Medical University,Harbin 150040 |
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| Abstract: | Objective: To explore the adjustment of whole peptidoglycans of bifidobacteria to macrophage functions.Methods: The level of interleukin 1, tumor necrosis factor a and nitric oxide (NO) produced by peritoneal macrophages of nude mice was detected by employing mouse thymocyte proliferation method killing L929 cell method in vitro and Griess reagent, after whole peptidoglycans were injected into the nude mice peritoneally.Simultaneously, tumoricidal activity of the macrophages in vitro was observed. Results: The content of interleukin 1, tumor necrosis factor a and nitric oxide (NO) secreted from peritoneal macrophages of nude mice was significantly higher in the whole peptidoglycan group when compared with the control group. Futhermore, the tumoricidal activity of the macrophages in vitro was markedly promoted (P < 0 .01 ). Conclusion: Whole pepti- doglycans of bifidobacteria bifidum could activated macrophages to secrete a lot of cytotoxicity effectors, and elevate its tumoricidal activity. |
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| Keywords: | bifidobacterium whole peptidoglycan macrophage cytokine nitric oxide |
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