果糖二磷酸钠对2型糖尿病大鼠周围神经传导功能的影响

目的：研究果糖二磷酸钠（FDP）对2型糖尿病（T2DM）大鼠周围神经病变的影响。方法：首先建立T2DM大鼠模型,将实验动物分成4组,正常对照组、模型对照组、FDP高剂量治疗组（5mL.kg-1.d-1,i.p.）和FDP低剂量治疗组（2mL.kg-1.d-1,i.p.）,每组8只。8周末,测定大鼠尾运动神经传导速度（MCV）、感觉神经传导速度（SCV）,H反射中H与M波的潜伏期,血清血糖（FBG）与超氧化物歧化酶（SOD）、一氧化氮合酶（NOS）的变化。结果：①与正常组比较,FDP干预前,T2DM大鼠FBG、血清胰岛素（FINS）水平显著升高,胰岛素敏感指数（ISI）显著降低（P〈0.01）;②FDP干预后,与正常组比较,模型对照组FBG、FINS水平显著升高,ISI、SOD、NOS和MCV、SCV显著下降,H与M波潜伏期显著延长（P〈0.01）;③与模型对照组比较,FDP干预后,高剂量组大鼠FBG、FINS水平显著降低,ISI、SOD、NOS、MCV和SCV显著升高,H与M波潜伏期显著缩短（P〈0.01）;低剂量组大鼠FBG显著降低,SOD、NOS、MCV和SCV显著升高,M波潜伏期显著缩短（P〈0.01或P〈0.05）;④与低剂量治疗组比较,高剂量组大鼠FBG、FINS水平显著降低,ISI、SOD、NOS、MCV和SCV显著升高,H与M波潜伏期显著缩短,（P〈0.01或P〈0.05）。结论：FDP对糖尿病大鼠周围神经病变具有一定的治疗作用,其机制可能与FDP降低糖尿病大鼠FBG和提高机体抗氧化能力有关。

Effects of Fructose Sodium Diphosphate on Peripheral Nerve Conduction Function with Type 2 Diabetes Rats

Objective：To study the effects of fructose sodium diphosphate（FDP） on peripheral nerve conduction function with type 2 diabetes mellitus（T2DM） rats.Methods：Male Wistar rats were developed the model of T2DM,these rats were divided into four groups（n=8）：normal control group,model control group,high dose group（5mL·kg-1·d-1,i.p.）,low dose group（2mL·kg-1·d-1,i.p.）.The treatment group rats were received FDP for 8 weeks,the following parameters were measured on：the fasting blood sugar（FBG）,SOD,NOS,insulin and the sensitivity index（FINS,ISI）,movement nerve conduction velocity（MCV）,sensory nerve conduction velocity（SCV）,incubation period of H wave and M wave in the H-reflex.Results：①Compared with normal control group,FBG,FINS and the incubation period of H wave and M wave in the model control group were significantly increased;ISI,SOD,NOS,MCV and SCV were significantly decreased（P〈0.01）;②Compared with model control group,in the high-dosage groups,the FBG,FINS and incubation period of H wave and M wave were significantly decreased;ISI,SOD,NOS,MCV and SCV were significantly increased（P〈0.01）;in low doses groups,the FBG,SOD,NOS,and incubation period of M wave were significantly decreased;the MCV and SCV were significantly increased（P〈0.05）.③Compared with low doses groups,in the high-dosage groups,the FBG,FINS and incubation period of H wave and M wave were significantly decreased;ISI,SOD,NOS,MCV and SCV were significantly increased（P〈0.01 or P〈0.05）.Conclusion：FDP may prevent and treat the diabetic peripheral neuropathy in T2DM rats,the FBG decrease and the antioxidation enhancement may play an important role.