基因-环境相互作用与人类疾病的关系

分子生物学技术的飞速发展通过对人类基因的鉴别和诊断,使人们对疾病的发生与发展有了更深刻的认识。现代科学观点认为个体差异的产生不能归结为完全的遗传因素或完全的环境因素,事实上,绝大多数人类疾病是遗传易感性和环境因子相互作用的结果。基因-环境交互作用可以理解为遗传因素对环境因素易感性的影响。本文从环境污染物对基因的影响、环境应答基因对疾病易感性的影响及基因-环境相互作用与环境基因组计划三方面对基因-环境相互作用与人类疾病的关系加以阐述。

The relationship between gene-environment interaction and human diseases

The development of molecular biological technologies for locating and identifying human genes is creating new opportunities for advances in our understanding of human disease.The current scientific view is that neither genetics nor environment is solely responsible for producing individual variation,and that virtually all traits show gene-environment interaction.Gene-environment interaction is best conceived of as the genetic control of sensitivity to the environment.This paper sums up and reviews new researches and studies in the field of the relationship between gene-environment interaction and human diseases.