|
|||||
|
|
Depression and Oral FTC/TDF Pre-exposure Prophylaxis (PrEP) Among Men and Transgender Women Who Have Sex With Men (MSM/TGW) |
|
| Authors: | Patricia A Defechereux Megha Mehrotra Albert Y Liu Vanessa M McMahan David V Glidden Kenneth H Mayer Lorena Vargas K Rivet Amico Piotr Chodacki Telmo Fernandez Vivian I Avelino-Silva David Burns Robert M Grant for the iPrEx Study Team |
| Institution: | 1.J. David Gladstone Institutes,San Francisco,USA;2.Bridge HIV,San Francisco Department of Public Health,San Francisco,USA;3.University of California,San Francisco,USA;4.Fenway Community Health,Boston,USA;5.Investigaciones Medicas en Salud,Lima,Peru;6.School of Public Health,University of Michigan,Ann Arbor,USA;7.Desmond Tutu HIV Foundation,University of Cape Town,Cape Town,South Africa;8.Fundacion Ecuatoriana Equidad,Guayaquil,Ecuador;9.University of Sao Paulo Medical School,Sao Paulo,Brazil;10.National Institutes of Health,Bethesda,USA;11.San Francisco AIDS Foundation,San Francisco,USA |
| Abstract: | We conducted a longitudinal and cross-sectional analysis of depressive symptomology in iPrEx, a randomized, placebo-controlled trial of daily, oral FTC/TDF HIV pre-exposure prophylaxis (PrEP) in men and transgender women who have sex with men. Depression-related adverse events (AEs) were the most frequently reported severe or life-threatening AEs and were not associated with being randomized to the FTC/TDF arm (152 vs. 144 respectively OR 0.66 95 % CI 0.35–1.25). Center for Epidemiologic Studies Depression scale (CES-D) and a four questions suicidal ideation scale scores did not differ by arm. Participants reporting forced sex at anal sexual debut had higher CES-D scores (coeff: 3.23; 95 % CI 1.24–5.23) and were more likely to have suicidal ideation (OR 2.2; 95 % CI 1.09–4.26). CES-D scores were higher among people reporting non-condom receptive anal intercourse (ncRAI) (OR 1.46; 95 % CI 1.09–1.94). We recommend continuing PrEP during periods of depression in conjunction with provision of mental health services. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |