允许性高碳酸血症通气法治疗呼吸窘迫综合征

目的：探讨允许性高碳酸血症通气法在治疗呼吸窘迫综合征中的价值。方法：随机选择46例需机械通气治疗的呼吸窘迫综合征患儿分为两组，对照组以传统通气方式治疗；允许性高碳酸血症通气法（治疗组）调节吸气峰压、呼气末压力、平均气道压等通气条件，维持血气PaCO2在45～55mmHg。比较两组通气条件、通气过程中血气值、并发症发生率和．病死率。结果：两组在通气过程中，氧舍指数（PaO2／FiO2）、pH值7LPaO2差异无显著性（P〉0．05），PaCO2差异有显著性（P〈0．01），允许性高碳酸血症通气法组上机时间显著减少（P〈0．05），气漏等并发症发生率明显降低．可降低病死率。结论：允许性高碳酸血症通气法在呼吸窘迫综合征治疗中较传统通气方式能降低并发症的发生率和缩短通气时间。

Permissive hypercapnia ventilation in the treatment of respiratory distress syndrome

Objective To explore the values of permissive hypercapnia ventilation in the treatment of respiratory distress syndrome.Methods Forty-six patients with respiratory distress syndrome were divided into two groups.The control group received traditional ventilation.The treatment group of permissive hypercapnia ventilation kept PaCO_2 from 45 to 55 mmHg by adjusting the parameters of PIP,PEEP and MAP.Respiratory parameters,blood gas value,complicated incidences and mortalities were compared between two groups.Results There was no significant difference in OI(PaO_2 /FiO_2),pH and PaO_2(P>0.05).PaCO_2 was increased significantly in permissive hypercapnia ventilation group(P<0.01),and the time of ventilation,complication incidences and mortalities were decreased significantly.Conclusion Permissive hypercapnia ventilation can more effectively reduce the complication incidences and shorten the time of mechanical ventilation in the treatment of respiratory distress syndrome.