Serum cytokine profiles in patients with Plasmodium vivax malaria: a comparison between those who presented with and without hepatic dysfunction |
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Authors: | Yeom Joon-Sup Park Se-Ho Ryu Seung-Ho Park Hae-Kyung Woo So-Youn Ha Eun-Hee Lee Bo-Eun Yoo Kwon Lee Joo-Ho Kim Kwang-Ho Kim Sunhil Kim Young-A Ahn Sun-Young Oh Sejoong Park Hyung-Joo Min Gi-Sik Seoh Ju-Young Park Jae-Won |
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Affiliation: | Department of Internal Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Pyung-Dong 108, Jongro-Ku, Seoul 110-746, Republic of Korea. |
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Abstract: | The aim of this study was to compare the serum cytokine profiles of Plasmodium vivax malaria patients who presented with and without hepatic dysfunction. This is a retrospective analysis of 74 consecutive cases of P. vivax malaria seen at 3 military hospitals near the Demilitarized Zone in South Korea from 1999 to 2000. All patients studied were adult active duty servicemen. On admission, the mean (+/- SEM) age of the patients who presented with (n = 36) and without hepatic dysfunction (n = 38) was 21.6 +/- 0.24 and 22.5 +/- 0.44 years, respectively (P = 0.72). On admission, there was no significant difference between the 2 patient populations in terms of mean temperature, haemoglobin level, haematocrit, total white blood cell count, platelet count, parasite index, and serum concentration of transforming growth factor-beta. Plasmodium vivax malaria patients who presented with hepatic dysfunction had significantly higher mean serum concentrations of soluble Fas ligand, interleukin (IL)-l, IL-4, IL-6, IL-10, tumor necrosis factor-alpha, and interferon-gamma than those without hepatic dysfunction, suggesting the involvement of these cytokines in the development of hepatic dysfunction. The mean serum concentration of IL-12 was significantly lower in patients with hepatic dysfunction. The mean body temperature was not significantly different between the 2 patient populations. |
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Keywords: | malaria Plasmodium vivax cytokines hepatic dysfunction South Korea |
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