| 广西壮族D6S477等四个STR基因座的遗传多态性 |
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| 引用本文： | 曹枝,滕少康,黄世宁,黄昌盛. 广西壮族D6S477等四个STR基因座的遗传多态性[J]. 解剖科学进展, 2007, 13(2): 134-137 |
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| 作者姓名： | 曹枝 滕少康 黄世宁 黄昌盛 |
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| 作者单位： | 广西右江民族医学院生物化学教研室,广西百色533000;广西右江民族医学院人体解剖学教研室,广西百色533000 |
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| 基金项目： | 广西青年科学基金资助(NO.桂科青0640075)，广西右江民族医学院2004年重点课题. |
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| 摘 要： | 目的 研究广西壮族人群4个STR（short tandem repeats）基因座：D6S477、D18S865、D19S400、D20S161的遗传多态性。方法 应用PCR扩增结合聚丙烯酰胺凝胶电泳技术分析200名广西壮族无关个体。结果 4个STR基因座平均期望杂合度为0．8442，平均多态信息总量为0．8247，累积个体识别力达0．999994474，累积非父排除率达0．9856。D6S477的等位基因15、D18S865的等位基因10和11、D19S400的等位基因11、D20S161的等位基因18可能是广西壮族群体中相应STR基因座最原始的等位基因。结论 广西壮族的4个STR基因座属高度遗传多态性。
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| 关 键 词： | 短串联重复序列(STR) 遗传多态性 壮族 |
| 文章编号： | 1006-2947（2007）02-0134-04 |
| 修稿时间： | 2007-02-14 |
Genetic Polymorphisms of D6S477,D18S865,D19S400 and D20S161 in Zhuang Ethnic Group of Guangxi Province |
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| CAO Lin-zhi,TENG Shao-kang,HUANG Shi-ning,HUANG Chang-sheng. Genetic Polymorphisms of D6S477,D18S865,D19S400 and D20S161 in Zhuang Ethnic Group of Guangxi Province[J]. Progress of Anatomical Sciences, 2007, 13(2): 134-137 |
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| Authors: | CAO Lin-zhi TENG Shao-kang HUANG Shi-ning HUANG Chang-sheng |
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| Affiliation: | Department of Biochemistry,Youjiang Medical college for nationalities,Guangxi Bose 533000 China |
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| Abstract: | Objective To investigate the genetic polymorphisms for four short tandem repeats (STR) loci (D6S477,D18S865,D19S400,D20S161)in Zhuang Ethnic in Guangxi province.Methods 200 unrelated individuals were analyed using polymerase chain reaction technique combined with polyacrylamide gel electrophoresis. Results The average expected heterozygosity in the four STR loci was 0.8442, the average polymorphism information content was 0.8247,the accumulative discrimination power was 0.999994474 and the accumulative probability of paternity exclusion was 0.9856. Allele 15 in D6S477, allele 10 and 11 in D18S865, allele 12 in D19S400 ,18 in D20S161 was probably the most primitive allele in respective locus. Conclusion The data obtained possess highly genetic polymorphisms . |
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| Keywords: | short tandem repeats(STR) genetic polymorphisms Zhuang Ethnic |
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