(英文)SD大鼠新奇环境反应性与海洛因依赖易感性的关系

目的:建立大鼠海洛因依赖易感性差异的条件性位置偏爱模型,进一步探讨新奇环境反应性与海洛因成瘾易感性之间的关系.方法:70只雄性SD大鼠分别进行旷场实验以了解其在新奇环境中的反应性,然后根据海洛因诱导的条件性位置偏爱的强度不同分为高CPP组和低CPP组,各占总数的30%, 并分析其与新奇环境反应性之间的关系.结果:海洛因处理前后实验大鼠CPP值差异有统计学意义(P<0.01);高CPP组旷场实验跨格总数及运动总距离均明显高于低CPP组(P<0.01);CPP的差值与旷场实验结果呈正相关(P<0.05).结论:小剂量递增法可以有效地建立海洛因CPP易感性差异模型.大鼠在新奇环境中的反应性能够较好地预测其形成海洛因依赖的强度.

Novel environmental response and heroin-dependent susceptibility in Sprague-Dawley rats

Objective To establish models of different susceptibility of heroin-induced conditioned place preference (CPP) in rats and investigate the relation between novel environmental response and heroin-dependent susceptibility. Methods After an open-field test, 70 male Sprague-Dawley rats were classified into 2 groups according to the numerical value of heroin-induced CPP, each accounting for 30%. The correlation between open-field test and CPP was analyzed. Results CPP value was much higher than pre-test scores in the rats after exposure to heroin (P<0.01). Compared with the low-CPP group, the high-CPP group had much higher scores in open-field test (P<0.01). The deviation of resident time at natural preference side tested and pre-tested had positive correlation with open-field test (P<0.05). Conclusion Heroin-induced CPP model of different susceptibilities could be successfully established by chronic heroin exposure. The novel environmental response is a reliable predictor for its vulnerability to develop heroin dependence.