| 人脑星形细胞瘤中p53,bcl—2基因表达的研究 |
| |
| 引用本文： | 莫立根,曾先捷,等.人脑星形细胞瘤中p53,bcl—2基因表达的研究[J].医学文选,2001,20(5):598-599. |
| |
| 作者姓名： | 莫立根 曾先捷 |
| |
| 作者单位： | 广西医科大学肿瘤医院，广西医科大学肿瘤医院，广西医科大学肿瘤医院，广西医科大学病理生理教研室 南宁市530021，南宁市530021，南宁市530021 |
| |
| 摘 要： | 目的：探讨p53,bcl-2基因在人脑星形细胞瘤发生发展中的作用。以及上述基因蛋白检测对星形细胞瘤的诊断，分级的临床意义。方法：采用免疫组化S－P染色法对47例人脑星形细胞瘤组织蜡块标本进行p53,bcl-2基因蛋白检测。结果：47例脑星形细胞瘤中p53,bcl-2蛋白的阳性率分别为48．9％（23／47），57．4％（27／46），其中多形性胶质母细胞瘤的p53基因蛋白阳性水平高于星行细胞瘤，而bcl-2蛋白阳性水平则是星行细胞瘤高于多形性胶质母细胞瘤。结论：p53,bcl-2基因的异常表达与人脑星形细胞瘤的发生，发展有密切关系，对星形细胞瘤的病理分级和预后判断有积极的意义。
|
| 关 键 词： | 星形细胞瘤 基因 免疫组织化学 |
investigation Of p53 and bcl-2 gene expression in human brain astrocytoma |
| |
| MO Ligen,ZENG Xianjie,XU Jian,et al The Affiliated Cancer Hospital Gang xi Medical University,NanNing China.investigation Of p53 and bcl-2 gene expression in human brain astrocytoma[J].Anthology of Medicine,2001,20(5):598-599. |
| |
| Authors: | MO Ligen ZENG Xianjie XU Jian The Affiliated Cancer Hospital Gang xi Medical University NanNing China |
| |
| Institution: | MO Ligen,ZENG Xianjie,XU Jian,et al The Affiliated Cancer Hospital Gang xi Medical University,NanNing 530021 China |
| |
| Abstract: | Objective To realize the significance of p53 and bcl 2 genes in the development and pathologic diagnosis of human brain astrocytoma Methods 47 cases of gliomas were detected by S P immunohistochemical staining Result Expression of p53 and bcl 2 proteins were positive in 48 9% (23/47), 57 4% (27/47) respectively; p53 expresssion of glioblastoma multiply was more high than p53 expresssion of astrocytoma, whereas most astrocytoma was positive bcl 2 protein Conclusion The two genes play an important role in the development of astrocytoma; the detection of these genes proteins has a positive significance on malignancy determination for astrocytoma |
| |
| Keywords: | astrocytoma gene immunohistochemistry |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
