ZPSJ方对2型糖尿病胰岛素抵抗患者胰岛素敏感性的影响

目的 观察ZPSJ方对2型糖尿病胰岛素抵抗患者胰岛素敏感性及其血清抵抗素、相关炎症因子的影响.方法 采用随机对照的方法,将80例2型糖尿病胰岛素抵抗患者分为两组各40例,治疗组采用ZPSJ方治疗, 对照组口服二甲双胍治疗.结果 两组治疗后血糖、血清胰岛素水平、HOMA-IR均明显降低(t=7.14,P<0.01); 组间比较:FPG、FINS差异无统计学意义,TG、TCH、HOMA-IR差异有统计学意义,治疗组较对照组明显降低(t =2.62,P<0.05).治疗组治疗后血清IL-6、TNF-a、hs-CRP均下降(f=1,85,P<0.05),对照组TNF-a、hs-CRP 下降(t=2.56,P<0.05),IL-6变化差异无统计学意义(P>0.05),两组治疗前后血清抵抗素水平比较无统计学意 义(P>0.05).结论 燥湿解毒,助脾散精中药复方有调节血糖、血脂并改善2型糖尿病胰岛素抵抗患者体内胰岛素 敏感性之作用.

Effects of ZPSJ Recipe on Insulin Sensitivity,Serum Resistin and Inflammatory Factors in Type 2 Diabetic Patients with Insulin Resistance

Objective To Observe the influence of Zaoshi Jiedu Zhupi Sanjing (ZPSJ) Recipe on insulin sensitivity, serum resistin and inflammatory factors related to the effects of Chinese herbal compound in type 2 diabetic patients with insulin resistance. Methods A single-blind randomized controlled clinical trial was conducted. 80 patients with 2 type diabetic patients with insulin resistance were recruited into a control group and a treatment group. The treatment group was treated with ZPSJ Recipe, and the control group was treated with metformin. Results In each group before and after treatment: blood glucose, serum insulin levels, HOMA-IR were significantly decreased (t=7.14, P<0.01 ) ; between the two groups, FPG, FINS showed no significant difference, while TG TCH, HOMA-LR showed significantly differences (t=2.62, P <0.05 ). Within the two groups before and after the treatment: serum IL-6, TNF-a, hs-CRP were decreased in treatment group, (t= 1.85, P<0.05 ) , while TNF-a, hs-CRP were decreased in the control group (t=2.56, P<0.05 ) , while IL-6 did not change significantly. The serum resistin levels were not statistically changed in both groups before and after treatment. Conclusion ZPSJ Recipe can regulate blood sugar, blood fat and improve insulin sensitivity in type 2 diabetic patients with insulin resistance.