Insulin secretion and glucose tolerance in non-insulin dependent diabetic patients after chronic nifedipine treatment |
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Authors: | A. Tentorio G. Ghilardi A. Pedroncelli R. Benco S. Stroppa S. Adib D. Gianola G. Pagani |
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Affiliation: | (1) Department of Endocrinology, Diabetes Unit, United Hospitals of Bergamo, Bergamo, Italy |
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Abstract: | Summary The effect of nifedipine 40 mg·day–1 for 3 months on glucose tolerance, insulin and C-peptide secretion after an oral glucose tolerance test (OGTT), intra-venous glucose tolerance test (IVGTT) and glucagon stimulatory test, has been studied in 8 moderately hypertensive women suffering from non-insulin dependent diabetes mellitus (NIDDM).No significant variation in glucose metabolism was noted after nifedipine treatment, except for a slight improvement in insulin secretion after OGTT at the end of the study. There was an increase in cholesterol as a collateral effect. |
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Keywords: | nifedipine diabetes mellitus NIDDM insulin secretion glucose tolerance serum cholesterol |
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