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Kinetics of Serologic Responses to MERS Coronavirus Infection in Humans,South Korea |
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| Authors: | Wan Beom Park Ranawaka A.P.M. Perera Pyoeng Gyun Choe Eric H.Y. Lau Seong Jin Choi June Young Chun Hong Sang Oh Kyoung-Ho Song Ji Hwan Bang Eu Suk Kim Hong Bin Kim Sang Won Park Nam Joong Kim Leo Lit Man Poon Malik Peiris Myoung-don Oh |
| Affiliation: | Seoul National University College of Medicine, Seoul, South Korea (W.B. Park, P.G. Choe, S.J. Choi, J.Y. Chun, H.S. Oh, K.-H. Song, J.H. Bang, E.S. Kim, H.B. Kim, S.W. Park, N.J. Kim, M.-d. Oh); ;The University of Hong Kong, Pokfulam, Hong Kong, China (R.A.P.M. Perera, E.H.Y. Lau, L.L.M. Poon); ;Hong Kong University–Pasteur Research Pole, Pokfulam (M. Peiris) |
| Abstract: | We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests. In most patients, robust antibody responses developed by the third week of illness. Delayed antibody responses with the neutralization test were associated with more severe disease. |
| Keywords: | Middle East respiratory syndrome coronavirus MERS-CoV Middle East respiratory syndrome MERS coronavirus antibody kinetics immunity severity viruses South Korea clinical correlates serologic responses diagnostics seroepidemiologic data humans |