Decrease in insulin secretion related to hypocalcemia induced by a high dose of zinc in rats |
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| Authors: | M Yamaguchi K Takahashi |
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| Affiliation: | Department of Environmental Biochemistry, Shiwoka College of Pharmacy, 2-2-1, Oshika, Shizuoka City, 422 Japan |
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| Abstract: | A single oral administration of zinc (Zn), sufficient to induce hypocalcemia, caused a decrease in glucose tolerance in fasted rats. This decrease resulted from reduction of insulin secretion. The restoration of Zn-induced hypocalcemia completely prevented the decrease in glucose tolerance and insulin secretion. These results suggest that the effect of Zn administration on insulin secretion in rats is a consequence of hypocalcemia. |
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| Keywords: | Zinc hypocalcemia insulin secretion glucose tolerance |
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