乳腺癌手术前后血清CA15-3和CEA水平与病理参数的相关性研究

目的探讨乳腺癌患者手术前后血清中CA15-3和CEA水平与病理参数的相关性。方法随机选择2012年6月至2014年7月南通市第四人民医院外科和南通市肿瘤医院肿瘤科共计267例乳腺癌患者为研究对象,采用电化学发光免疫分析法检测所有患者术前一周、术后1月血清中CA15-3和CEA水平,并分析CA15-3和CEA水平与乳腺癌患者临床病理参数的相关性。结果 267例乳腺癌患者术前一周血清中CA15-3和CEA水平分别为35.6±11.41U/ml和8.9±3.4ng/ml,术后1月分别为20.1±9.23U/ml和4.1±1.7ng/ml,P0.05,差异具有统计学意义;Ⅲ和Ⅳ期癌症患者的CA15-3和CEA阳性表达率均明显高于Ⅰ和Ⅱ期,肿瘤有多处转移的CA15-3和CEA阳性表达率明显高于1处转移的,术后复发患者的CA15-3和CEA阳性表达率高于没有复发患者,P0.05,差异均具有统计学意义;采用不同手术类型患者术后CA15-3和CEA阳性表达率无显著性差异,P0.05。结论乳腺癌患者血清中CA15-3和CEA水平与癌症TNM分期、转移、术后复发具有相关性,便于及时诊断术后癌症转移复发。

Relationships of serum CA15-3 and CEA levels to pathological parameters in patients with breast cancer preoperative and postoperative

Objective To investigate the correlation of serum carbohydrate antigen 15-3 (CA15-3) and carcinoembryonic anti-gen (CEA) levels and pathological parameters in preoperative or postoperative breast cancer patients. Methods 267 cases of pa-tients with breast cancer were randomly collected in this study from the department of surgery of Nantong Fourth People ’s Hospital and the department of oncology of Nantong tumor hospital between June 2012 and July 2014. Electrochemical luminescence im-munoassay (ECLI) technology was used to measure serum levels of CEA and CA15-3 one week before and one month after the surgery. The relationships between CA15-3,CEA levels and clinicopathological parameters were analyzed. Results The serum CA15-3 and CEA levels of one week before surgery (35.6 ±11.41U/ml,8.9 ±3.4ng/ml) were significantly higher than that of one month after the surgery (20.1±9.23U/ml,4.1±1.7ng/ml) (P<0.05). The CA15-3 and CEA positive expression rates with histological grade Ⅲand Ⅳ was significantly higher than that of patients in Ⅰ and Ⅱ,and the CA15-3 and CEA positive expression rates of patients with multiple tumor metastasis were significantly higher than that of patients with one ,and the CA15-3 and CEA positive expression rate of patients with recurrence were higher than that of patients with no recurrence (P<0.05). There was no significant difference between patients received different types of surgery in the CA15-3 and CEA positive expression rates (P>0.05). Con-clusion The serum CA15-3 and CEA levels of breast cancer patients was associated with TNM stage,postoperative metastasis and recurrence and could be considered as the judgment standard for cancer metastasis and recurrence postoperative.