急性脑梗死介入治疗的疗效观察

目的观察急性脑梗死患者行动脉内溶栓治疗的临床疗效。方法41例急性脑梗死患者采用超选择脑动脉内溶栓方法，起病距溶栓时间3～24h，尿激酶以1.0万U／min持续泵入，总量为120万U，辅助其它常规治疗，治疗14d后评价其临床疗效。结果溶栓有效率为87.8％，显效率68.3％，血管再通率为80.48％，治疗后神经功能缺损评分较前显著降低（P〈0.01）。结论动脉内溶栓治疗急性缺血性脑梗死是一种安全有效的方法，可使大部分患者闭塞动脉再通，提高临床治疗效果。

Effect of interventional therapy in Acute cerebral infarction

Objective To present a retrospective analysis of the clinical outcome in patients treated by local intra-arterial thrombolysis （LITT） with urokinase for acute ischemic stroke of the anterior or posterior arterial circulation. Methods 41patients with acute cerebral infarction were treated by superselective infra-arterial thrombolysis in 3-24hours after onset of the symptoms of cerebral infarction. Urokinase （UK） was infused into the infracted cerebral artery at the rate of 10 000 unit/min. The total dosage of UK was 1 200 000 units. The patients were given routine treatment. The curative effect were evaluated 14 days after the treatment. Results The rate of effective, excellence, recanalization were 87.8% and 68,3% and 80.48% respectively.The neurological deficit scale score was significantly lower than before （P〈0.01）. Conclusion Intra-arterial thrombolysis is a safe and effective therapy for acute ischemic cerebral infarction.