多烯磷脂酰胆碱联合复方甘草酸苷治疗NAFLD的疗效观察

目的观察多烯磷脂酰胆碱联合复方甘草酸苷治疗非酒精性脂肪肝(NAFLD)的临床疗效。方法 56例非酒精性脂肪肝患者随机分为治疗组(30例)和对照组(26例),对照组给予复方甘草酸苷治疗;治疗组给予多烯磷脂酰胆碱和复方甘草酸苷联合治疗,疗程均为12周。治疗结束后比较两组临床疗效及血清学各指标变化。结果治疗组总有效率(86.7%)明显优于对照组(73.1%,P<0.05);治疗结束后治疗组ALT、AST、TG、TC和LDL-C等指标较对照组显著降低(P<0.05),HDL-C较对照组显著升高(P<0.05)。结论多烯磷脂酰胆碱联合复方甘草酸苷治疗非酒精性脂肪肝疗效显著,安全可靠,值得临床推广应用。

Clinical efficacy study of polyene phosphatidylcholine combined with compound glycyrrhizin in treatment of non-alcoholic fatty liver

Objective To investigate the clinical efficacy of polyene phosphatidylcholine combined with compound glycyrrhizin in treatment of non-alcoholic fatty liver. Methods 56 patients with non-alcoholic fatty liver were randomly divided into treatment group（n= 30） and control group（n= 26）. The control group was treated with compound glycyrrhizin, and the treatment group was treated with polyene phosphatidylcholine. The treatment duration lasted 12 weeks for both groups. The clinical efficacy and serological indicators changes of two groups were compared after treatment. Results The total effective rate of treatment group （86.7%） was significantly better than that of control group （73. 1%）（P〈 0. 05） ;The levels of ALT,TC, LDL-C and TG in treatment group after treatment were significantly lower than that of control group, but the level of HDL-C was significantly higher than that of control group（P〈0. 05）. Conclusion The treatment of polyene phosphatidylcholine combined with compound glycyrrhizin for non-alcoholic fatty liver had a good effect, without adverse reaction. It should be worthy of clinical application.