| SLE血小板聚集功能及茶黄烷醇类物质对其影响 |
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| 引用本文： | 徐根波,李翠琴.SLE血小板聚集功能及茶黄烷醇类物质对其影响[J].中华皮肤科杂志,1996,29(4):237-239. |
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| 作者姓名： | 徐根波 李翠琴 |
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| 作者单位： | 浙江医科大学附属第二医院 |
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| 摘 要： | ６０例ＳＬＥ患者血小板自发聚集率和花生四烯酸、二磷酸腺苷诱导的聚集率较正常人明显升高（Ｐ＜０．０１），尤以活动期、伴肾损害和补体下降者为甚。血小板自发聚集率与循环免疫复合物增高呈正相关，提示其可作为ＳＬＥ患者高凝状态的观察指标之一。茶黄烷醇类物质能抑制各种诱导剂诱导的ＳＬＥ患者血小板的聚集，且随着浓度增加而增加，并能提高聚集后血浆环磷酸腺苷水平，提示茶黄烷醇类物质可能作用于前列腺素代谢的中间环节，对ＳＬＥ伴高凝状态的治疗具有一定价值。
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| 关 键 词： | 红斑狼疮.系统性 血小板凝集 茶黄烷醇类物质 |
TheFunctionofPlateletAggregationinSLEandtheEfectofTeaFlavanols |
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| XuGenbo,LiCuiqin,WangShijiong,et al..TheFunctionofPlateletAggregationinSLEandtheEfectofTeaFlavanols[J].Chinese Journal of Dermatology,1996,29(4):237-239. |
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| Authors: | XuGenbo LiCuiqin WangShijiong |
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| Institution: | XuGenbo,LiCuiqin,WangShijiong,etal.TheSecondAffiliatedHospital,ZhejiangMedicalUniversity,Hangzhou310009 |
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| Abstract: | Therateofplateletspontaneousaggregationandtherateofaggregationinducedbyarachidonicacid(AA),andadenosinediphosphate(ADP)in60patientswithSLEweresignificantlyhigherthanthoseincontrols(P<0.01),especialyinthoseofprogresivestage,withrenallesionandhypocomplementemia.PlateletspontaneousaggregationratewaspositivelycorrelatedwithincreasedCICwhichsuggeststhatthespontaneousaggregationratecouldbeusedasoneoftheindexesforhyper-coagulationstateinSLE.Inaddition,itwasfoundthatteaflavanolscouldinhibitplateletaggregationinducedbyADP,adrenalineandAAinpatientswithSLE.Theefectofteaflavanolsincreasedwithin-creasingconcentrations,andcouldincreaseplasmacAMPlevelafterplateletaggregation.Itsuggeststhatteaflavanolsmayexertanactiononthemetaboliclinkinprostaglandins,andbeofvalueforthetreatmentofSLEpatientscomplicatedwithhypercoagulationstate. |
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| Keywords: | Lupuserythematosus systemicPlateletaggregationTeaflavanols |
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