| 黄连厚朴丸对实验性胃黏膜损伤、腹泻和呕吐的影响 |
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| 引用本文： | 潘怀耿,李茹柳,李卫民,徐颂芬,叶富强,陈蔚文.黄连厚朴丸对实验性胃黏膜损伤、腹泻和呕吐的影响[J].中国新药杂志,2004,13(2):126-128. |
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| 作者姓名： | 潘怀耿 李茹柳 李卫民 徐颂芬 叶富强 陈蔚文 |
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| 作者单位： | 1. 广州中医药大学,脾胃研究所,广州,510405
2. 广州中医药大学,中药学院,广州,510405 |
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| 摘 要： | 目的:观察黄连厚朴丸对实验性胃黏膜损伤、腹泻和呕吐的影响.方法:采用盐酸乙醇、氢氧化钠、吲哚美辛致大鼠急性胃黏膜损伤模型、小鼠番泻叶致泻模型和家鸽呕吐模型.结果:黄连厚朴丸不同剂量均有抗盐酸乙醇、氢氧化钠、吲哚美辛致大鼠胃黏膜损伤的作用;促进小鼠小肠水分吸收,明显减少番泻叶致小鼠腹泻的湿粪数;并能明显减少硫酸铜致家鸽呕吐次数.结论:黄连厚朴丸有保护胃黏膜损伤、止泻和止呕作用.
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| 关 键 词： | 黄连厚朴丸 急性胃黏膜损伤 腹泻 呕吐 |
| 文章编号： | 1003-3734(2004)02-0126-03 |
Effects of Huanglian Houpu pill on the acute gastric mucosal damage,diarrhea and vomiting models in animals |
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| PAN Huai-geng,LI Ru-liu,LI Wei-min,XU Song-fen,YE Fu-qiang,CHEN Wei-wen.Effects of Huanglian Houpu pill on the acute gastric mucosal damage,diarrhea and vomiting models in animals[J].Chinese Journal of New Drugs,2004,13(2):126-128. |
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| Authors: | PAN Huai-geng LI Ru-liu LI Wei-min XU Song-fen YE Fu-qiang CHEN Wei-wen |
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| Abstract: | Objective:To study the effects of Huanglian Houpu pill (HLHP) on the acute gastric mucosal damage, diarrhea and vomiting models in animals. Methods: The acute gastric mucosal damage model in rats induced by HCl-ethanol, NaOH and indomethacin, and the diarrheal model in mice induced by senna and vomiting model in pigeon induced by copper sulfate were used to observe the HLHP' S pharmacological effects on gastrointestinal tract. Results: HLHP at different doses had antagonistic effect on gastric mucosal damage in rat s models. It can obviously reduce the diarrhea and vomiting frequency in mice and pigeon model respectively. Conclusion: HLHP has antagonistic effect on gastric mucosal damage and it also has antidiarrheal and antiemetic effects. |
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| Keywords: | Huanglian Houpu pill acute gastric mucosal damage diarrhea vomiting |
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