Automated synthesis of 18F‐labelled analogs of metomidate,vorozole and harmine using commercial platform |
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| Authors: | Obaidur Rahman Maria Erlandsson Elisabeth Blom Bengt Långström |
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| Institution: | 1. Uppsala Applied Science Laboratory, GE Healthcare, SE‐752 28 Uppsala, Sweden;2. Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, Husargatan 3, BMC, S‐751 23 Uppsala, Sweden |
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| Abstract: | Three 18F‐labelled PET tracers, 2‐18F]fluoroethyl 1‐(1R)‐1‐phenylethyl]‐1H‐imidazole‐5‐carboxylate (18F]FETO), 6‐(S)‐(4‐chlorophenyl)‐(1H)‐1,2,4‐triazol‐1‐yl)methyl]‐1‐(2‐18F]fluoroethyl)‐1H‐benzotriazole (18F]FVOZ) and 7‐2‐(2‐18F]fluoroethoxy)ethoxy]‐1‐9H‐ β ‐carboline (18F]FHAR) were synthesized by a one‐step nucleophilic fluorination using the automated commercial platform TRACERLab FXFN. The labelled products were obtained with 16–20% isolated decay corrected radiochemical yields after 70–75 min synthesis time. The radiochemical and chemical purities were more than 98% in all cases. The synthesis using commercial platform may make these tracers more accessible for clinical research. Copyright © 2010 John Wiley & Sons, Ltd. |
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| Keywords: | PET 18F‐labelling [18F]FETO [18F]FVOZ [18F]FHAR automated synthesis |
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