Evaluation of SNPs in miR‐146a,miR196a2 and miR‐499 as low‐penetrance alleles in German and Italian familial breast cancer cases |
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| Authors: | Irene Catucci Rongxi Yang Paolo Verderio Sara Pizzamiglio Ludwig Heesen Kari Hemminki Christian Sutter Barbara Wappenschmidt Michelle Dick Norbert Arnold Peter Bugert Dieter Niederacher Alfons Meindl Rita K. Schmutzler Claus C. Bartram Filomena Ficarazzi Laura Tizzoni Daniela Zaffaroni Siranoush Manoukian Monica Barile Marco A. Pierotti Paolo Radice Barbara Burwinkel Paolo Peterlongo |
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| Affiliation: | 1. IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy;2. Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;3. Division Molecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University of Heidelberg, Vo?strasse 9, 69115 Heidelberg, Germany;4. Helmholtz‐University Group Molecular Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany;5. Unit of Medical Statistics and Biometry, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;6. Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany;7. Clinical Research Center, Malm?, Sweden;8. Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany;9. Division of Molecular Gyneco‐Oncology, Department of Gynaecology and Obstetrics, Clinical Center University of Cologne, 50931 Cologne, Germany;10. Division of Oncology, Department of Gynaecology and Obstetrics, University Hospital Schleswig‐Holstein, Arnold‐Heller‐Str. 3, house 24. 24105 Kiel, Germany;11. Institute of Transfusion Medicine and Immunology, Red Cross Blood Service of Baden‐Württemberg‐Hessen, University of Heidelberg, Medical Faculty of Mannheim, Friedrich‐Ebert‐Str. 107, 68167 Mannheim, Germany;12. Division of Molecular Genetics, Department of Gynaecology and Obstetrics, Clinical Center University of Düsseldorf, 40225, Düsseldorf, Germany;13. Department of Gynecology and Obstetrics, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany;14. Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;15. Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy;16. Scientific Direction, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy |
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| Abstract: | Recently, the SNPs rs11614913 in hsa‐mir‐196a2 and rs3746444 in hsa‐mir‐499 were reported to be associated with increased breast cancer risk, and the SNP rs2910164 in hsa‐mir‐146a was shown to have an effect on age of breast cancer diagnosis. In order to further investigate the effect of these SNPs, we genotyped a total of 1894 breast cancer cases negative for disease‐causing mutations or unclassified variants in BRCA1 and BRCA2, and 2760 controls from Germany and Italy. We compared the genotype and allele frequencies of rs2910164, rs11614913 and rs3746444 in cases versus controls of the German and Italian series, and of the two series combined; we also investigated the effect of the three SNPs on age at breast cancer diagnosis. None of the performed analyses showed statistically significant results. In conclusion, our data suggested lack of association between SNPs rs2910164, rs11614913 and rs3746444 and breast cancer risk, or age at breast cancer onset. © 2009 Wiley‐Liss, Inc. |
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| Keywords: | genetic susceptibility breast cancer risk miRNA rs11614913 rs3746444 rs2910164 |
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