[carbonyl‐11C]Benzyl acetate: Automated radiosynthesis via Pd‐mediated [11C]carbon monoxide chemistry and PET measurement of brain uptake in monkey |
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Authors: | Shuiyu Lu Jinsoo Hong Tetsuji Itoh Masahiro Fujita Osamu Inoue Robert B. Innis Victor W. Pike |
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Affiliation: | 1. Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892‐1003, USA;2. Division of Health Sciences, Graduate School of Medicine, Osaka University, 1‐7 Yamadaoka, Suita, Osaka 565‐0871, Japan |
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Abstract: | [carbonyl‐11C]Benzyl acetate ([11C]1) has been proposed as a potential agent for imaging glial metabolism of acetate to glutamate and glutamine with positron emission tomography. [11C]1 was synthesized from [11C]carbon monoxide, iodomethane and benzyl alcohol via palladium‐mediated chemistry. The radiosynthesis was automated with a modified Synthia platform controlled with in‐house developed Labview software. Under production conditions, [11C]1 was obtained in 10% (n=6) decay‐corrected radiochemical yield from [11C]carbon monoxide in >96% radiochemical purity and with an average specific radioactivity of 2415 mCi/µmol. The total radiosynthesis time was about 45 min. Peak uptake of radioactivity in monkey brain (SUV=3.1) was relatively high and may be amenable to measuring uptake and metabolism of acetate in glial cells of the brain. Published in 2010 by John Wiley & Sons, Ltd. |
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Keywords: | [11C]benzyl acetate carbon‐11 [11C]carbon monoxide carbonylation PET |
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