Cigar and pipe smoking and cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) |
| |
| Authors: | Valerie A. McCormack Antonio Agudo Christina C. Dahm Kim Overvad Anja Olsen Anne Tjonneland Rudolf Kaaks Heiner Boeing Jonas Manjer Martin Almquist Goran Hallmans Ingegerd Johansson Maria Dolores Chirlaque Aurelio Barricarte Miren Dorronsoro Laudina Rodriguez Maria Luisa Redondo Kay‐Tee Khaw Nick Wareham Naomi Allen Tim Key Elio Riboli Paolo Boffetta |
| |
| Affiliation: | 1. International Agency for Research on Cancer, Lyon, France;2. Unit of Nutrition Environment and Cancer, Catalan Institute of Oncology, Barcelona, Spain;3. Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark;4. Department of Epidemiology, Institute of Public Health, Aarhus University, Aarhus, Denmark;5. Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark;6. German Cancer Research Centre, Heidelberg, Germany;7. German Institute of Human Nutrition Potsdam‐Rehbrucke, Nuthetal, Germany;8. Department of Surgery, Malm? University Hospital, Lund University, Malm?, Sweden;9. Department of Surgery, Lund University Hospital, Lund University, Lund, Sweden;10. Nutritional Research, Department of Public Health and Clinical Medicine, Ume? University, Ume?, Sweden;11. Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain;12. CIBER Epidemiología y Salud Pública (CIBERESP), Spain;13. Public Health Institute, Navarra, Pamplona, Spain;14. Department of Public Health of Guipuzkoa, San Sebastian, Spain;15. Population Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain;16. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom;17. MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom;18. Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom;19. Department of Epidemiology and Population Health, Imperial College, London, United Kingdom;20. The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY;21. International Prevention Research Institute, Lyon, France;22. Tel.: +33 6 58 38 67 24 |
| |
| Abstract: | The carcinogenicity of cigar and pipe smoking is established but the effect of detailed smoking characteristics is less well defined. We examined the effects on cancer incidence of exclusive cigar and pipe smoking, and in combination with cigarettes, among 102,395 men from Denmark, Germany, Spain, Sweden and the United Kingdom in the EPIC cohort. Hazard ratios (HR) and their 95% confidence intervals (CI) for cancer during a median 9‐year follow‐up from ages 35 to 70 years were estimated using proportional hazards models. Compared to never smokers, HR of cancers of lung, upper aerodigestive tract and bladder combined was 2.2 (95% CI: 1.3, 3.8) for exclusive cigar smokers (16 cases), 3.0 (2.1, 4.5) for exclusive pipe smokers (33 cases) and 5.3 (4.4, 6.4) for exclusive cigarette smokers (1,069 cases). For each smoking type, effects were stronger in current smokers than in ex‐smokers and in inhalers than in non‐inhalers. Ever smokers of both cigarettes and cigars [HR 5.7 (4.4, 7.3), 120 cases] and cigarettes and pipes [5.1 (4.1, 6.4), 247 cases] had as high a raised risk as had exclusive cigarette smokers. In these smokers, the magnitude of the raised risk was smaller if they had switched to cigars or pipes only (i.e., quit cigarettes) and had not compensated with greater smoking intensity. Cigar and pipe smoking is not a safe alternative to cigarette smoking. The lower cancer risk of cigar and pipe smokers as compared to cigarette smokers is explained by lesser degree of inhalation and lower smoking intensity. |
| |
| Keywords: | cancer cigar pipe smoking |
|
|
