| 慢性次声作用后对小鼠海马内IL-6的影响 |
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| 引用本文： | 牟翔 李玲 袁华 易南 刘静 陈景藻. 慢性次声作用后对小鼠海马内IL-6的影响[J]. 中国康复医学杂志, 2005, 20(10): 739-740,T0002 |
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| 作者姓名： | 牟翔 李玲 袁华 易南 刘静 陈景藻 |
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| 作者单位： | 解放军第四军医大学西京医院康复理疗科,陕西西安,710032 |
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| 基金项目： | 军队医药卫生科研基金“九五”重点课题（962042）,全军医药卫生科研基金“十五”指令性课题（01L071） |
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| 摘 要： | 目的：研究慢性次声作用后对小鼠海马内白细胞介素-6（IL-6）的影响。方法：BALB／C小鼠暴露于16Hz．声压级90dB次声，2h／d，分别作用1d、7d、14d、21d和28d后，采用免疫组织化学方法观察小鼠海马内IL-6的变化。结果：次声作用一定时间后，IL-6阳性胶质细胞主要分布在海马CAl-CA4区和齿状回，且随次声作用天数增加，IL-6阳性胶质细胞数目增多。结论：小鼠海马对次声较为敏感，IL-6表达的增高对神经系统可能有保护作用。
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| 关 键 词： | BALB／C小鼠 次声作用 IL-6 海马内 慢性 免疫组织化学方法 胶质细胞 白细胞介素 数目增多 保护作用 |
| 文章编号： | 1001-1242（2005）-10-0739-02 |
| 收稿时间： | 2005-08-05 |
| 修稿时间： | 2005-08-05 |
Effects on interleukin-6 in the hippocampus of the mouse exposed to chronic infrasound |
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| MOU Xiang,LI Ling,YUAN Hu,et al.. Effects on interleukin-6 in the hippocampus of the mouse exposed to chronic infrasound[J]. China Journal of Rehabilitation Medicine, 2005, 20(10): 739-740,T0002 |
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| Authors: | MOU Xiang LI Ling YUAN Hu et al. |
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| Abstract: | Objective:To study effects on the expression of interleukin-6(IL-6) in the hippocampus of the mouse exposure to chronic infrasound.Method:The BALBC mice were exposed to infrasound of 16Hz with an intensity of 90dB for 1d,7d,14d,21d and 28d. It was applied 2h per day. Then immunohistochemical technique was employed to detect the change of IL-6 in the hippocampus of the mice. Result:The expression of IL-6 increased mainly in the CA1-CA4 areas and dentate gyrus of the hippocampus after infrasound of 90dB exposure.IL-6 immunoreactive glia cells increased at the same time.Conclusion: The extent of IL-6 change is closely related to the times of exposure under infrasound of equal sound pressure level. Mice hippocampus is sensitive to the infrasound and the increase of IL-6 may offer protective effects. |
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| Keywords: | infrasound brain injury interleukin-6 |
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