| 电针对大鼠不稳定膀胱逼尿肌及膀胱颈氮能神经递质的影响 |
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| 引用本文： | 陈跃来,岑珏,侯文光,高志强,虞先敏,马雪梅. 电针对大鼠不稳定膀胱逼尿肌及膀胱颈氮能神经递质的影响[J]. 中西医结合学报, 2006, 4(1): 73-75 |
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| 作者姓名： | 陈跃来 岑珏 侯文光 高志强 虞先敏 马雪梅 |
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| 作者单位： | 上海中医药大学岳阳中西医结合医院针灸科,上海市针灸推拿临床医学中心,上海,200437 |
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| 基金项目： | 上海市教委科技发展基金资助项目(No.02ck02)，上海市针灸推拿学重点学科资助项目(No.T0302) |
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| 摘 要： | 目的:观察电针治疗对大鼠不稳定膀胱模型下尿路组织氮能神经递质的影响。方法:制作大鼠不稳定膀胱模型,电针会阳、中膂俞7d后,采用免疫组织化学法检测大鼠膀胱逼尿肌、膀胱颈平滑肌神经源性一氧化氮合酶(neuronal nitric oxide synthase,nNOS)、内皮型一氧化氮合酶(endothelial nitric oxide syn-thase,eNOS)和诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)阳性细胞并计数。结果:不稳定膀胱模型其膀胱逼尿肌、膀胱颈平滑肌中氮能神经递质明显下降,而电针治疗则可促进氮能神经递质的生成和分泌。结论:电针促进膀胱组织中氮能神经递质的生成和分泌可能是电针治疗改善不稳定膀胱功能的主要机制之一。
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| 关 键 词： | 电针 不稳定膀胱 氮能神经递质 动物实验 |
| 文章编号： | 1672-1977（2006）01-0073-03 |
| 收稿时间： | 2005-05-07 |
| 修稿时间： | 2005-05-07 |
Effects of electroacupuncture treatment on nitrergic neurotransmitter in bladder neck and detrusor of rats with unstable bladder |
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| Yue-Lai CHEN,Jue CEN,Wen-Guang HOU,Zhi-Qiang GAO,Xian-Min YU,Xue-Mei MA. Effects of electroacupuncture treatment on nitrergic neurotransmitter in bladder neck and detrusor of rats with unstable bladder[J]. Journal of Chinese integrative medicine, 2006, 4(1): 73-75 |
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| Authors: | Yue-Lai CHEN Jue CEN Wen-Guang HOU Zhi-Qiang GAO Xian-Min YU Xue-Mei MA |
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| Affiliation: | Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai Acupuncture-Moxibustion-Tuina Medical Center, Shanghai 200437, China |
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| Abstract: | OBJECTIVE: To observe the effects of electroacupuncture treatment on nitrergic neurotransmitter in bladder neck and detrusor of rats with unstable bladder. METHODS: Rat models of unstable bladder were established by operation to induce urethral obstruction. Electroacupuncture treatment was given by acupuncturing Huiyang and Zhonglushu points for a week. Then the neuronal nitric oxide synthase (nNOS)-, endothelial nitric oxide synthase (eNOS)- and inducible nitric oxide synthase (iNOS)-positive cells in bladder neck and detrusor of the rats were observed. RESULTS: The nitrergic neurotransmitter in bladder neck and detrusor were obviously decreased in rats with unstable bladder. The electroacupuncture treatment could significantly increase the contains of NOS in bladder tissue. CONCLUSION: To promote the synthesis and secretion of nitrergic neurotransmitter in bladder tissue may be one of the mechanisms of acupuncture in adjusting bladder function. |
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| Keywords: | electroacupuncture unstable bladder nitrergic neurotransmitter animals experimentation |
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