| 癫(癎)儿童脑内代谢变化的1HMRS研究 |
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| 引用本文： | 虞志康,严志汉,周云新,林加瑜.癫(癎)儿童脑内代谢变化的1HMRS研究[J].温州医学院学报,2007,37(6):543-546. |
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| 作者姓名： | 虞志康 严志汉 周云新 林加瑜 |
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| 作者单位： | 温州医学院第二附属医院,影像科,浙江,温州,325027 |
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| 基金项目： | 浙江省温州市科技局资助项目 |
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| 摘 要： | 目的:探讨磁共振质子波谱(1HMRS)在儿童癫(癎)中的应用.方法:对24例颞叶癫(癎)及额叶癫(癎)患儿进行1HMRS采集.测定N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱复合物(Cho)、乳酸(Lac)、谷氨酸及谷氨酰胺(Glu及Gln)、r-氨基丁酸(GABA)等代谢产物,并以15例非颅内病变患儿作为对照.结果:癫(癎)组病侧与癫(癎)组对侧和对照组NAA/(Cho Cr)比较,差异有显著性(P＜0.01),癫(癎)组病侧与癫(癎)组对侧和对照组NAA/Cho比较,差异亦有显著性(P＜0.01).结论:1HMRS可无创探测小儿癫(癎)致癫灶内神经元受损及功能异常的代谢生化改变,有助于小儿癫(癎)的定位诊断.
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| 关 键 词： | 癫(癎) 磁共振 质子波谱 |
| 文章编号： | 1000-2138（2007）06-0543-04 |
| 收稿时间： | 2006-08-14 |
Research of magnetic resonance spectroscopy on changes of the intracerebral metabolism in epileptic children |
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| YU Zhi-kang, YAN Zhi-han, ZHOU Yun-xin, et al.Research of magnetic resonance spectroscopy on changes of the intracerebral metabolism in epileptic children[J].Journal of Wenzhou Medical College,2007,37(6):543-546. |
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| Authors: | YU Zhi-kang YAN Zhi-han ZHOU Yun-xin |
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| Abstract: | Objective:To explore the application of magnetic resonance spectroscopy (1HMRS) in the diagnosis of pediatric epilepsy. Methods: 1HMRS were performed in 24 children with temporal lobe epilepsy (TLE) and frontal lobe epilepsy, 15 children without intracranial disease were used as controls. The concentration of N-acetylaspartate(NAA), Creatine (Cr), Choline-containing (Cho), glutamate and glutamime (Glu/Gln) and lactate (Lac) were measured in all epilepsy and controls. Results: The concentration of NAA and ratio of NAA/(cho/cr) in epileptogenic foci were significantly lower than that of sites on the opposite and control group (P<0.01). Conclusion: 1HMRS can detect the neuron injury and changes of cerebral metabolism in pediatric epilepsy. |
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| Keywords: | epilepsy magnetic resonance spectroscopy |
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