| Acting via A_2 receptors，adenosine inhibits H_2O_2 production and elastase releaseon FMLP一stimulated |
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| 作者单位： | Department of Cardiology，The First CIinical College; Department of Toxicology，The School of Preventive Medicine |
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| 摘 要： | ＡｃｔｉｎｇｖｉａＡ２ｒｅｃｅｐｔｏｒｓ，ａｄｅｎｏｓｉｎｅｉｎｈｉｂｉｔｓＨ２Ｏ２ｐｒｏｄｕｃｔｉｏｎａｎｄｅｌａｓｔａｓｅｒｅｌｅａｓｅｏｎＦＭＬＰ一ｓｔｉｍｕｌａｔｅｄｎｅｕｔｒｏｐｈｉｌｓＺｈａｎｇＹｕ，ＢａＴｕ（ＤｅｐａｒｔｍｅｎｔｏｆＣａ...
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Acting via A2 receptors, adenosine inhibits H2 O2 production and elastase release on FMLP一stimulated neutrophils |
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| Zhang Yu,Ba Tu. Acting via A2 receptors, adenosine inhibits H2 O2 production and elastase release on FMLP一stimulated neutrophils[J]. Journal of Jilin University: Med Ed, 1995, 0(3) |
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| Authors: | Zhang Yu Ba Tu |
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| Abstract: | In agreement with Previous results,activation of adenosine A2 receptors wasfound to inhibit the exocytotic release of elastase and the oxidative burst induced by formyl一MetLeuPhe( f MLP ) in human neutrophils.The effects of adenosine were not influenced by the selective Al-adenosine receptor antagonist 1,3-dipropyl-8-cyclopentylxanthine(DPCPX;300nM),but were abolished by the non-selective adenosine receptor antagonist 9-chloro-2-(2-furanyl)-5,6-dihydro-[1,2,4]-triazolo[1,5]quinazolin-5-imine monomethane-sulfonate(CGS 15943;10μM).Adenosine did not altcr fMLP一induced inositol一(1,4,5)一trisphosphate(InsP3 ) formation. These data suggest that the inhibitory effects of adeno-sine on neutrophil functions may be related to an action of adenosine occurring late in the se- quence of events of signal transduction |
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| Keywords: | adenosine CGS15943 DPCPX neutrophils oxygen free radical granu-locyte elastase IP3 |
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