检测原发性卵巢癌和转移性卵巢癌CDX2、CK7、CA_(125)表达的临床意义

目的:通过检测卵巢原发性上皮性癌和卵巢转移性结直肠腺癌中尾型同源盒转录因子2(CDX2)、细胞角蛋白7(CK7)、糖链抗原125(CA_(125) )的表达情况,探讨其临床意义。方法:选取卵巢原发性上皮性癌82例,原发性结直肠腺癌50例,卵巢转移性结直肠腺癌35例,通过免疫组化法检测CDX2、CK7、CA_(125) 的表达情况并进行分析比较。结果:CDX2在原发性结直肠腺癌和卵巢转移性结直肠腺癌中的阳性表达率(分别为100.0%和85.7%)明显高于卵巢原发性上皮性癌(13.4%),差异有统计学意义(P0.001)。CK7、CA_(125) 在卵巢原发性上皮性癌中的阳性表达率(分别为57.3%和73.2%)明显高于原发性结直肠腺癌(分别为26.0%和4.0%)和卵巢转移性结直肠腺癌(分别为22.9%和5.7%),差异有统计学意义(P0.001)。卵巢原发性上皮性癌联合检测CK7、CA_(125) 的阳性表达率(91.5%)高于单个指标(CA_(125) 为73.2%,CK7为57.3%),差异有统计学意义(P0.001)。结论:卵巢原发性上皮性癌中CK7和CA_(125) 高表达,可作为其抗体检测指标。CK7和CA_(125) 联合检测可提高卵巢原发性上皮性癌的检出率。

The Clinical Significance of Expression of CDX2,CK7 and CA125 in Primary Ovarian Cancer and Metastatic Ovarian Cancer

Objective:To investigate the expressions of CDX2,CK7 and CA125 in primary epithelial ovarian cancer and metastatic colorectal adenocarcinoma,and to explore its clinical significance.Methods:82 cases of primary epithelial ovarian cancer,50 cases of primary colorectal adenocaminoma,35 cases of ovarian metastatic colorectal adenocaminoma were selected.The expressions of CDX2,CK7 and CA125 were detected by immunohistochemistry and were analyzed.Results:The positive expression rate of CDX2 in primary colorectal adenocarcinoma and ovarian metastasis colorectal adenocarcinoma was 100.0％ and 85.7％,respectively,which were significantly higher than that of primary ovarian epithelial carcinoma (13.4％),the difference was statistically significant(P ＜0.001).The positive expression rate of CK7 and CA125 in primary ovarian epithelial cancer rates was 57.3％ and 73.2％,respectively,which was significantly higher than that of primary colorectal adenocarcinoma (26.0％ and 4.0％) and ovarian metastatic colorectal adenocarcinoma(22.9％ and 5.7％),the difference was statistically significant(P ＜0.001).The positive expression rate(91.5％) of the combined detection of CA125 and CK7 was higher than that of single index(CA125 73.2％,CK7 57.3％),and the difference was statistically significant(P ＜ 0.001).Conclusions:The expressions of CK7 and CA125 are high in primary epithelial ovarian cancer,thus they can be used as tumor marker of primary epithelial ovarian cancer.Combined detection of CK7 and CA125 can improve the detection rate of primary epithelial ovarian cancer.