生长激素缺乏儿童垂体MRI测量值与患儿生长激素激发峰值的关系

目的 分析生长激素缺乏症(GHD)儿童垂体MRI测量值与其生长激素(GH)激发峰值的相关性.方法 收集46例GHD患儿作为观察组,选择同期来本院体检的30例健康儿童作为对照组,比较2组垂体MRI测量值差异,分析垂体MRI测量值与GH激发峰值的相关性.结果 ①与≤6岁相比,对照组7~10岁、>10岁,观察组>10岁冠状高径、矢状高径均增加(P<0.05),对照组矢状前后径同样增加(P<0.05),与同性别、同年龄对照组相比,观察组患儿冠状高径、矢状前后径、矢状高径均降低(P<0.05);②与≤6岁相比,7~10岁、>10岁观察组、对照组GH激发峰值均上升(P<0.05),观察组同性别、同年龄GH激发峰值均低于对照组(P<0.05);③GHD垂体MRI冠状高径、矢状高径与GH激发峰值呈正相关,其中冠状高径相关度最高(P<0.05).结论 GHD患儿垂体MRI冠状高径、矢状高径均与GH激发峰值呈正相关,监测GH水平的变化可预测儿童生长发育状况.

Relationship between measured diameters of pituitary gland on MRI and peak-stimulated growth hormone levels in children with growth hormone deficiency

Objective To analyze the relationship between the measured diameters of pituitary gland on MRI and peak-stimulated growth hormone(GH) in children with growth hormone deficiency (GHD).Methods A total of 46 children with GHD were included in this study, and 30 healthy children who were admitted to the hospital for health check-up were acted as the control group during the same period.The measured diameters of pituitary gland on MRI were compared between the two groups and the correlation between the diameters of pituitary gland on MRI and peak-stimulated GH were analyzed.Results ① The coronary and sagittal heights of pituitary gland on MRI were greater in children aged 7-10 years old and older than 10 years in control group and in children older than 10 years in observation group than those in children younger than 6 years (P<0.05).The anteroposterior diameter of pituitary gland on sagittal MRI in the control group was increased (P<0.05).The coronal height, sagittal anteroposterior diameter and sagittal height were lower in the observation group compared with age-and gender-matched controls(P<0.05).②The peak-stimulated growth hormone levels were higher in children aged 7-10 years old and older than 10 years in both groups compared with children younger than 6 years old (P<0.05).The peak-stimulated GH were lower in observation group compared with age-and gender-matched controls(P<0.05).③ The heights of pituitary gland on coronary and sagittal MRI in children with GHD were positively related to the peak-stimulated GH, and coronary height had the highest correlation(P<0.05).Conclusion The heights of pituitary gland on coronary and sagittal MRI in children with GHD are positively related to the peak-stimulated GH.The growth and development of children can be predicted by monitoring the changes of GH levels.