抑郁症及其一级亲属脑基础活动的BOLD-fMRI研究

目的 运用功能磁共振成像(fMRI)研究抑郁症(MDD)及其一级亲属静息状态下脑区的低频振幅(ALFF)及低频振幅比率(fALFF)的特点及差异,以了解MDD患者早期的脑功能状态.方法 对10例MDD患者(MDD组)、10例MDD一级亲属(一级亲属组)、10例健康志愿者(对照组)进行3.0T静息状态脑功能磁共振成像 (fMRI),分别计算各组的ALFF、fALFF,进行统计学分析.结果 与一级亲属组相比,MDD组的左侧小脑、左侧楔前叶、左侧内侧前额叶皮质的ALFF、fALFF值均显著性降低(P<0.05);而右侧背侧扣带回皮质、右侧顶上小叶的ALFF值显著减低(P<0.05);与对照组相比,MDD组的左侧小脑、左侧楔前叶、左侧顶上小叶的ALFF、fALFF值均显著性降低(P<0.05),而右侧扣带回皮质、内侧前额叶皮质的ALFF值显著减低(P<0.05);一级亲属组与对照组相比,ALFF值无统计学差异,一级亲属组的左侧顶上小叶的fALFF值显著降低(P<0.05).结论 MDD患者及一级亲属脑区均存在广泛的ALFF、fALFF异常,这些异常的脑区可能与MDD认知网络障碍及情感低落相关.

BOLD-fMRI study on the basic activity of the brain in major disorder depression and their first-degree relatives

Objective To study the characteristics and differences of the amplitude of low-frequency fluctuation (ALFF) and the fractional ALFF (fALFF) of the major disorder depression (MDD) and their first-degree relatives in the resting state by functional magnetic resonance imaging (fMRI),to understand the early brain function in patients with MDD.Methods 3.0T fMRI in the resting state was performed in 10 patients with MDD (the depression group),10 first-degree relatives of MDD (the first-degree relatives group) and 10 healthy volunteers (the control group).A statistics analysis of ALFF and fALFF were performed subsequently.Results The ALFF and fALFF values measured in left cerebellum, left precuneus and left medial prefrontal cortex of MDD group were significantly lower than those of the first-degree relatives group (P<0.05).The ALFF values measured in right posterior cingulate cortex and right superior parietal lobule of MDD group were significantly lower than those of the first-degree relatives group (P<0.05).The ALFF and fALFF values measured in left cerebellum, left precuneus and left superior parietal lobule of MDD group were significantly lower than those of the control group (P<0.05).The ALFF values measured in right cingulate cortex and medial prefrontal cortex of MDD group were significantly lower than those of the control group (P<0.05).There was no significance difference found in ALFF values between the first-degree relatives group and the control group,the fALFF values measured in left superior parietallobule of the first-degree relatives group were significantly lower than those of the control group (P<0.05).Conclusion As the widespread ALFF, fALFF abnormalities of brain in MDD and first-degree relatives of MDD,a hypothesis can be get that these abnormal brain region may be associated with cognitive network disorders and emotional distress in MDD.