围绝经期抑郁症前扣带回的磁共振波谱研究

目的 探讨围绝经期抑郁症前扣带回区γ-氨基丁酸(GABA)含量的变化.方法 40例围绝经期女性为实验组,10例健康女性为对照组,随访18~24个月,采用氢质子磁共振波谱(1H-MRS)技术检测其大脑前扣带回区GABA浓度,实验组分别于绝经前及绝经后各测量1次,对照组分别在入组时及出组时各测量1次.实验组于绝经后根据中国精神障碍分类与诊断标准第3版(CCMD-3)及汉密尔顿焦虑量表(HAMA-14)、汉密尔顿抑郁量表(HAMD-17)的评分结果分为焦虑组和抑郁组,分别比较3组GABA的差异.结果 焦虑组及抑郁组绝经后GABA水平较绝经前显著降低(P<0.05),并均较健康对照组低(P<0.05);抑郁组患者绝经后GABA水平较焦虑组患者绝经后低(P<0.05).结论 前扣带回GABA水平改变与围绝经期抑郁症的病理生理机制联系密切,与围绝经期抑郁症的症状也有联系.

A magnetic resonance spectroscopy study in the anterior cingulate cortex ofperimenopausal women with depression

Objective To investigate the changes of gamma-aminobutyric acid (GABA) in the anterior cingulate cortex of perimenopausal women with depression.Methods Forty perimenopausal women as the experimental group and ten healthy women as the control group were recruited and followed up for 18 to 24 months.The proton magnetic resonance spectroscopy (1H-MRS) was used to acquire the concentrations of GABA in the anterior cingulate cortex.The experimental group was examined before and after menopause.The control group was examined before into the group and after out of the group.The experimental group after menopause was further divided into the anxiety group and the depression group according to the Classification and Diagnostic Criteria of Mental Disorders in China-Third Edition (CCMD-3), 14-item Hamilton Anxiety Scale (HAMA-14) and 17-item Hamilton Depression Scale (HAMD-17).The data of three groups were compared respectively.Results The results showed that the concentrations of GABA after menopause in both of the anxiety group and depression group were significantly lower (P<0.05) than those before menopause, and were also significantly lower (P<0.05) than those in the control group.The concentrations of GABA after menopause in the depression group were significantly lower(P<0.05) than those in the anxiety group.Conclusion The changes of GABA in the anterior cingulate cortex are related with the pathophysiology mechanism of perimenopausal depression and the symptoms of perimenopausal depression.