海马体积测量联合 MMSE 评分在认知障碍中的应用

目的：探讨测量海马体积(HV)联合简易智力状况检查量表(MMSE)评分评估不同程度认知功能障碍的价值。方法收集阿尔茨海默病(AD)患者、轻度认知障碍(MCI)患者、正常对照(NC)各30例,应用西门子 MRI 行 HV 测量,综合分析3组患者标准化后的 HV、MMSE 评分。结果与 MCI、NC 组比较,AD 组总 HV、左右侧均减小,差别有统计学意义(P 值均<0.05)；MCI 与 NC 2组之间 HV 无显著差异；分析3组患者的 MMSE 评分,AD 组分值均小于 MCI、NC 组,差别有统计学意义(P 值均<0.05),MMSE 评分在MCI 与 NC 2组间无差别。结论HV 测量联合 MMSE 评分,有助于为 AD 患者诊断提供有价值的信息,而在 MCI 中的诊断灵敏度不高。

Hippocampal volume measurement with MMSE score in the application value of cognitive impairment

Objective To investigate the clinical application value of hippocampal volume (HV)measurement with MMSE score in varying different degrees cognitive impairment.Methods 30 Alzheimer’s disease(AD)patients,30 mild cognitive impairment (MCI)patients and 30 normal controls(NC)were recruited,HV was measured by Siemens Tim-avanto 3.0T super conductance magnetic resonance.Standardized HV and MMSE scores of three groups were comprehensive analyzed.Results The left and right sides and the total HV of AD group were lower than the MCI and the NC group,with significant differences by statistical analysis (P <0.05).The HV had no significant differences between the MCI and the NC group.The MMSE scores of AD group were lower than the MCI and the NC group,with significant differences by statistical analysis (P <0.05),the score had no significant differences between the MCI and the NC group.Conclusion HV measurement with MMSE score would be helpful to provide effective basis for the AD diagnosis,the sensitivity in the diagnosis of MCI is not high.