能谱CT成像对肝硬化不同肝叶血流动力学的对比研究

目的 探讨能谱CT成像基物质分离技术在肝硬化患者不同肝叶血流动力学改变中的临床应用.方法 收集本院30例临床确诊为肝硬化的患者,行上腹部能谱CT增强扫描,扫描后重建单能量图像及基物质分离图像,在碘-水配对基物质图像上分别测量动脉期(AP)、门静脉期(VP)肝脏5叶(尾状叶、左外叶、左内叶、右前叶、右后叶)碘浓度(IC)及同层面腹主动脉碘浓度(ICaorta),分别计算出肝脏各叶动脉期碘分数(AIF)、门静脉期碘含量(PVIC)、动脉期及门静脉期标准化碘浓度(NIC),比较不同肝叶动脉期及门静脉期碘浓度(ICAP,ICVP)、AIF、PVIC、动脉期及门静脉期标准化碘浓度(NICAP,NICVP)等参数的差异.采用单因素方差分析对数据进行统计处理.结果 肝硬化患者尾状叶ICAP、ICVP,NICAP、NICVP,AIF均高于肝脏其余4叶,差异有统计学意义(P<0.05),但在肝脏其余4叶之间无明显统计学意义(P>0.05);PVIC在尾状叶稍低于其余4叶,但结果无统计学意义(P=0.929).结论 能谱CT基物质分离技术(碘基图)定量测量肝脏各叶IC可以评价肝硬化患者不同肝叶血流动力学的改变和差异,为临床提供更多的肝硬化血流改变信息.

Comparative study of spectral CT on the hemodynamic changes of different liver lobes in cirrhotic liver

Objective To explore the clinical application of material decomposition technique on spectral CT imaging and evaluate hemodynamic changes in different liver lobes with liver cirrhosis.Methods 30 patients with liver cirrhosis diagnosed clinically in our hospital were collected and underwent enhanced scanning of abdomen with spectral CT protocol.The monochromatic energy images and iodine-based material decomposition (MD) images were reconstructed after scanning.The iodine concentration (IC) was measured in five liver lobes (the caudate, left lateral, left inner, right anterior and right posterior lobes) and the abdominal aorta of the same axial slice in both the arterial phase (AP) and portal venous phase (VP) on the iodine-water based material decomposition images.The arterial iodine fraction (AIF) and the portal venous iodine concentration (PVIC) as well as the normalized iodine concentration (NIC) during the AP and VP were calculated.The differences of IC,the NIC,the AIF,and the PVIC in five liver lobes in AP and VP were compared by using single factor analysis of variance.Results The IC,the NIC in both AP and VP and the AIF of the caudate liver lobe were higher than those of other four liver lobes, with statistically significant difference (P<0.05), while these values in the other four lobes showed no statistically significant difference (P>0.05).The PVIC of the caudate liver lobe was slightly lower than that of the other four liver lobes, however, the difference was not statistically significant (P=0.929).Conclusion The quantitative iodine concentration measurement of liver lobes on spectral CT material decomposition technique can evaluate the hemodynamic changes in liver lobes with liver cirrhosis,and provide more information about the change of blood flow in liver cirrhosis.