口腔癌前哨淋巴结活检价值的系统评价

目的:探讨前哨淋巴结活检(SLNB)对于判断口腔癌颈淋巴结转移的敏感性和特异性及临床预测价值.方法:计算机检索PubMed、EMBASE、CENTRAL、中国期刊全文、万方、中国生物医学文献等相关数据库,搜集已公开发表的有关SLNB预测口腔癌颈淋巴结转移的相关诊断试验,应用Meta-disc 1.4统计软件进行分析,评价SLNB预测口腔癌颈淋巴结转移敏感性、特异性和受试者工作特征曲线(ROC)下面积(AUC).结果:最终共25项诊断实验、934例受试者纳入本研究.Meta分析结果显示SLNB预测口腔癌颈淋巴结转移敏感性和特异性分别为91％(95％ CI 88％-94％)和100％(95％ CI 99％-100％);综合受试者工作特征曲线(SROC)下面积(AUC)为0.99.结论:SLNB预测口腔癌颈淋巴结转移敏感性、特异性均较高,作为判断颈淋巴结转移的标准有较高的临床应用价值.

Clinical efficacy of sentinel lymph node biopsy for oral cancer: A systematic review

Objective:To evaluate the clinical sensitivity and specificity of sentinel lymph node biopsy (SLNB) for oral cancer.Methods:By searching Medline,CENTRAL,EMBSE,CBM,CNKI,WANFANG,etc,an studies about SLNB for the patients with oral cancer array for lymph node metastasis were retrieved.The quality of included studies was evaluated by QUADAS items.The data were analyzed by statistic software Meta-DiSc 1.4.Results:25 studies including 934 subjects were analyzed in the current systematic review.The pooled values of sensitivity,specificity were 91％ (95％ CI 88％-94％) and 100％ (95 ％ CI 99％-100％) respectively.The area under summary receiver operating characteristic (SROC) curve (AUC) of SLNB for cervical lymph node metastasis was 0.99.Conclusion:SLNB procedure has high sensitivity and specificity in the diagnosis of cervical lymph node metastasis,it can be used as an useful method for cervical lymph node metastasis screening in patients with oral cancer.